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Antiretroviral drugs efavirenz, dolutegravir and bictegravir dysregulate blood-brain barrier integrity and function.

Author: BendayanReina, HoqueTozammel, HuangChang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the impact of antiretroviral drugs (ARVs) on the blood-brain barrier (BBB) integrity. Efavirenz, dolutegravir, and bictegravir, commonly used ARVs, were found to disrupt BBB integrity in both in vitro and in vivo models, suggesting a potential contribution to HIV-associated neurocognitive disorders (HAND). Specifically, dolutegravir, an integrase strand transfer inhibitor, showed a significant impact on BBB permeability, which may contribute to short-term neuropsychiatric side effects and the high incidence of mild HAND.
Paper Details　
Original Abstract of the Article :
The implementation of combined antiretroviral therapy (cART) significantly reduces the mortality associated with human immunodeficiency virus (HIV) infection. However, complications such as HIV-associated neurocognitive disorders (HAND) remain a major health concern. We hypothesized that the toxicit...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10030948/

データ提供：米国国立医学図書館（NLM）

HIV Antiretroviral Drugs and the Blood-Brain Barrier: A Complex Landscape in the Desert of HIV Treatment

Combined antiretroviral therapy (cART) has revolutionized the management of HIV infection, transforming a once-deadly disease into a chronic condition. However, the long-term effects of these medications on the brain remain a crucial area of research. This study investigates the impact of three commonly used antiretroviral drugs, efavirenz, dolutegravir, and bictegravir, on the blood-brain barrier (BBB), a protective shield that keeps harmful substances out of the brain.

Antiretroviral Drugs and BBB Integrity: Navigating the Dunes of Potential Complications

The study found that these antiretroviral drugs can disrupt the integrity and function of the BBB, potentially contributing to the development of HIV-associated neurocognitive disorders (HAND), a serious complication that can affect brain function. The drugs were shown to alter the expression of key proteins involved in BBB function, potentially increasing permeability and allowing harmful substances to enter the brain.

Protecting the Brain: Understanding the Potential Risks

This study raises important concerns about the potential long-term impact of antiretroviral drugs on brain health. Further research is needed to understand the specific mechanisms by which these drugs affect the BBB and to develop strategies for mitigating these risks. Close monitoring of patients receiving cART is crucial for detecting potential neurological complications and ensuring optimal long-term health outcomes.

Dr.Camel's Conclusion

This study sheds light on the complex relationship between antiretroviral drugs and the blood-brain barrier, emphasizing the importance of understanding the potential long-term neurological effects of these life-saving medications. While cART has revolutionized HIV treatment, continued research is crucial for ensuring optimal brain health in the long term, navigating the intricate landscape of HIV treatment and minimizing the risk of neurological complications.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-03-28
Further Info :

Pubmed ID

36969875

DOI: Digital Object Identifier

PMC10030948

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Languages

English

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