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Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis.

Author: AlbalawiRawan S, BagherAmina M, BinmahfouzLenah S, HareeriRawan H, ShaikRasheed A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Parthenolide (PTL) is a natural compound with potential therapeutic benefits. When formulated as phytosomes, PTL demonstrates enhanced bioavailability and protective effects against gentamicin-induced nephrotoxicity in rats. PTL-phytosomes alleviate kidney damage, reduce oxidative stress, and exhibit anti-inflammatory and anti-apoptotic properties.
Paper Details　
Original Abstract of the Article :
Nephrotoxicity is a serious complication that limits the clinical use of gentamicin (GEN). Parthenolide (PTL) is a sesquiterpene lactone derived from feverfew with various therapeutic benefits. However, PTL possesses low oral bioavailability. This study aimed to evaluate the therapeutic protective e...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10053629/

データ提供：米国国立医学図書館（NLM）

Protecting Kidneys from Gentamicin Toxicity

This research explores a promising approach to protecting kidneys from the damaging effects of gentamicin, an antibiotic commonly used to treat bacterial infections. The researchers investigated the therapeutic potential of parthenolide (PTL), a sesquiterpene lactone derived from feverfew, in mitigating gentamicin-induced nephrotoxicity. They formulated PTL as phytosomes to improve its oral bioavailability and evaluated its protective effects in rats. Their findings suggest that PTL-phytosomes effectively attenuated gentamicin-induced kidney damage, offering a potential strategy for reducing nephrotoxicity associated with this important antibiotic.

Parthenolide's Protective Effects

The study's findings demonstrate the protective effects of PTL-phytosomes against gentamicin-induced nephrotoxicity. The researchers observed that PTL-phytosomes significantly reduced kidney damage, improved kidney function, and mitigated oxidative stress and inflammation. This research highlights the potential of PTL as a therapeutic agent for protecting kidneys from drug-induced damage.

Potential for New Strategies in Nephrotoxicity Management

This research opens new avenues for managing drug-induced nephrotoxicity. The researchers' findings suggest that PTL-phytosomes could be a valuable addition to the therapeutic arsenal for protecting kidneys from damage caused by antibiotics and other medications. This research underscores the importance of developing new strategies for mitigating drug-induced side effects, improving patient safety and treatment outcomes.

Dr.Camel's Conclusion

This study offers a glimpse into the potential of natural compounds in protecting vital organs from drug-induced damage. The researchers' findings suggest that PTL-phytosomes may offer a safe and effective way to mitigate gentamicin-induced nephrotoxicity, opening new avenues for managing drug-related side effects. This research serves as a reminder that the vast world of nature holds untapped potential for therapeutic solutions.
Date :
  1. Date Completed 2023-03-30
  2. Date Revised 2023-03-31
Further Info :

Pubmed ID

36985711

DOI: Digital Object Identifier

PMC10053629

Related Literature

Article Analysis
・Effective treatment of feverfew
SNS
PICO Info
in preparation
Languages

English

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