Osimertinib and Selpercatinib Efficacy, Safety, and Resistance in a Multicenter, Prospectively Treated Cohort of EGFR-Mutant and RET Fusion-Positive Lung Cancers.

Author: AwadMark, CliffordSarah, DrilonAlexander, GoldmanJonathan W, HanleyMatthew P, HaradaGuilherme, KheraniJennifer, KuoChih-Hsi S, NechushtanHovav, OxnardGeoffrey R, PatelJyoti D, RajappaSenthil, RotowJulia, SantucciAlison, SchefflerMatthias, SilvaLaura, TupperRebecca, YuHelena

Paper Details 
Original Abstract of the Article :
Acquired RET fusions have been reported at resistance to treatment with EGFR inhibitors in EGFR-mutant non-small cell lung cancer (NSCLC); however, a multicenter cohort of patients with EGFR-mutant lung cancers treated with osimertinib and selpercatinib for RET fusion-mediated osimertinib resistance...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/36996322

データ提供:米国国立医学図書館(NLM)

Osimertinib and Selpercatinib: New Oases in the Desert of EGFR-Mutant Lung Cancers

EGFR-mutant non-small cell lung cancer (NSCLC) is a challenging disease, like a vast desert with few oases of effective treatments. This study explores the efficacy of osimertinib and selpercatinib, two promising new therapies, in treating this complex cancer.

Osimertinib and Selpercatinib: A Dual-Therapy Strategy in the Fight Against EGFR-Mutant NSCLC

The researchers analyzed data from a multicenter cohort of patients with EGFR-mutant lung cancers, revealing that osimertinib and selpercatinib, like two well-equipped caravans venturing into the desert, effectively managed EGFR-mutant NSCLC, including cases with acquired RET fusions. The study provides valuable insights into the potential of these therapies, especially in cases where osimertinib resistance has developed. This research offers hope for patients seeking effective treatments for this challenging form of cancer.

EGFR-Mutant Lung Cancers: Finding New Oases of Hope

EGFR-mutant lung cancers, like a formidable desert landscape, require innovative approaches to treatment. This study, like a team of scientists searching for new solutions, sheds light on the potential of osimertinib and selpercatinib as effective therapies for this complex cancer. It emphasizes the importance of continued research and development of new drugs to improve patient outcomes and bring hope to those battling this disease.

Dr. Camel's Conclusion

The study, like a caravan discovering a new oasis in a vast and unforgiving desert, offers hope for patients with EGFR-mutant lung cancers. Osimertinib and selpercatinib, like two refreshing springs, provide potential pathways towards improved outcomes and a better quality of life for these patients.

Date :
  1. Date Completed 2023-08-24
  2. Date Revised 2023-10-03
Further Info :

Pubmed ID

36996322

DOI: Digital Object Identifier

NIHMS1889723

Related Literature

SNS
PICO Info
in preparation
Languages

English

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