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Orexin receptor antagonists in the pathophysiology and treatment of sleep disorders and epilepsy.

Author: DehpourAhmad Reza, GhasemiMehdi, KhalilzadehMina, ShayanMaryam, SheibaniMohammad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review examines the intricate relationship between sleep, epilepsy, and orexin, a wake-promoting neuropeptide. Sleep disorders are commonly observed in epilepsy patients, and orexin has been shown to have a bidirectional influence on both sleep and epilepsy. While orexin initially was considered a potential target for insomnia treatment, its potential for psychiatric disorders and epileptic seizures is being explored in pre-clinical studies.
Paper Details　
Original Abstract of the Article :
The correlation between sleep and epilepsy has been argued over the past decades among scientists. Although the similarities and contrasts between sleep and epilepsy had been considered, their intertwined nature was not revealed until the nineteenth century. Sleep is recognized as a recurring state ...See full text at original site
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引用元：
https://doi.org/10.1016/j.npep.2023.102335

データ提供：米国国立医学図書館（NLM）

Sleep, Epilepsy, and Orexin: A Complex Web of Connections

Sleep and epilepsy, seemingly separate entities, are intricately linked. This research delves into the complex desert of their relationship, focusing on the role of orexin, a wake-promoting neuropeptide, in both sleep disorders and epilepsy. The researchers explored the potential of orexin receptor antagonists as therapeutic targets for managing both sleep disorders and epilepsy, highlighting the potential for a multi-faceted approach to these challenging conditions.

The Desert of Sleep and Epilepsy

The research reveals a complex interplay between sleep, epilepsy, and orexin. Orexin and its receptors play a crucial role in regulating sleep-wake cycles and may also influence seizure activity. The study suggests that orexin receptor antagonists, by targeting orexin signaling, could potentially provide benefits for both sleep disorders and epilepsy. Imagine these antagonists as guides navigating the complex desert of sleep and epilepsy, seeking to restore balance and harmony.

A New Frontier in Treatment

This research opens a new frontier in the treatment of sleep disorders and epilepsy, highlighting the potential of targeting orexin signaling pathways. While further research is needed to fully understand the implications of these findings, this study offers a promising glimpse into the complex world of sleep, epilepsy, and their intricate connections. Remember, the desert of health is vast and often unpredictable; exploring new pathways can lead to unexpected discoveries and potentially new avenues for healing.

Dr.Camel's Conclusion

The desert of sleep and epilepsy is often a challenging landscape to navigate. This research reveals a complex web of connections between these conditions, highlighting the potential role of orexin and its receptors in regulating both sleep and seizure activity. This study offers a promising glimpse into the potential of orexin receptor antagonists as therapeutic targets, suggesting a new avenue for treating both sleep disorders and epilepsy.

Date :
  1. Date Completed 2023-05-10
  2. Date Revised 2023-05-10
Further Info :

Pubmed ID

37003137

DOI: Digital Object Identifier

10.1016/j.npep.2023.102335

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Languages

English

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