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Oxidized soluble guanylyl cyclase causes erectile dysfunction in alcoholic mice.

Author: AnguloJavier, BarreiraBianca, ColadoMaria Isabel, FernándezArgentina, Gil de Biedma-ElduayenLeticia, Giménez-GómezPablo, O'SheaEsther, OlivenciaMiguel A, Perez-VizcainoFrancisco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that chronic intermittent ethanol exposure in mice led to erectile dysfunction (ED) due to alterations in the redox state of soluble guanylyl cyclase (sGC). This suggests that sGC activators may be effective in ED associated with alcoholism.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND PURPOSE: Alcohol abuse has been associated with erectile dysfunction (ED), but the implicated molecular mechanisms are unresolved. This study analyses the role of alterations in soluble guanylyl cyclase (sGC) in ED. EXPERIMENTAL APPROACH: ED was analysed in adult male C57BL/6J mice s...See full text at original site
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引用元：
https://doi.org/10.1111/bph.16087

データ提供：米国国立医学図書館（NLM）

Alcohol's Impact on Erectile Dysfunction: A New Perspective

Erectile dysfunction (ED) is a common condition that can significantly impact a man's quality of life and relationships. Researchers in the field of sexual medicine are constantly working to understand the causes and develop effective treatments for ED, aiming to improve patient well-being and restore sexual function. This study investigates the role of oxidized soluble guanylyl cyclase (sGC) in alcohol-induced ED, offering a new perspective on the mechanisms underlying this condition.

Alcohol and Oxidized sGC: A New Link to ED

This study provides strong evidence for a link between alcohol consumption and oxidized sGC in the development of ED. The researchers found that mice exposed to chronic intermittent ethanol (CIE) exhibited significant impairment in erectile function, as measured by intracavernosal pressure (ICP) and in vitro studies of isolated corpora cavernosa. The study also found that the impaired erectile function was associated with increased oxidative stress and altered sGC activity. These findings suggest that alcohol-induced oxidative stress may contribute to ED by impairing sGC function.

Implications for ED Treatment

This study's findings have important implications for ED treatment, highlighting the potential role of sGC activators in addressing alcohol-induced ED. The study suggests that sGC activators, which bypass the oxidation-dependent pathway, may be effective in restoring erectile function in men with alcohol-induced ED. However, further research is needed to confirm these findings and evaluate the safety and efficacy of sGC activators in this population.

Dr.Camel's Conclusion

This research is like a camel traversing a desert oasis, uncovering the hidden mechanisms underlying alcohol-induced erectile dysfunction. It reveals the potential role of oxidized sGC in this condition and suggests new avenues for treatment, offering hope for a better future for those struggling with ED.

Date :
  1. Date Completed 2023-08-10
  2. Date Revised 2023-08-26
Further Info :

Pubmed ID

37021655

DOI: Digital Object Identifier

10.1111/bph.16087

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in preparation
Languages

English

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