Paper Details

  1. Home
  2. Paper Details

Interactions between antifungals and everolimus against <i>Cryptococcus neoformans</i>.

Author: LiangPin, LiuQin, SongJiquan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cryptococcosis is a fungal infection that can cause pneumonia and/or meningoencephalitis. There are very few therapeutic options for cryptococcosis. This study examined the interaction of everolimus (EVL) with amphotericin B (AmB) and azoles (fluconazole, posaconazole, voriconazole, and itraconazole) against Cryptococcus. The results showed that EVL had antifungal activity against Cryptococcus and that the combination of EVL with AmB or azoles exhibited synergistic antifungal effects.
Paper Details　
Original Abstract of the Article :
Cryptococcus is the causal agent of cryptococcosis, a disease with high mortality mainly related to HIV immunosuppression and usually manifests with pneumonia and/or meningoencephalitis. There are very few therapeutic options; thus, innovative approaches are required. Herein, We examined the interac...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10070994/

データ提供：米国国立医学図書館（NLM）

Synergistic Antifungal Effects of Everolimus in Combination with Amphotericin B and Azoles Against Cryptococcus neoformans

This study explores the synergistic effects of everolimus (EVL) in combination with amphotericin B (AmB) and various azoles against Cryptococcus neoformans, a fungal pathogen causing cryptococcosis. The study uses a broth microdilution experiment to determine the minimum inhibitory concentrations (MICs) of these antifungal agents and analyzes their interactions using the fractional inhibitory concentration index (FICI). The results demonstrate synergistic antifungal effects of EVL in combination with AmB and azoles against a majority of C. neoformans strains tested. This research suggests that combining EVL with AmB or azoles could be a promising strategy for treating cryptococcosis.

Fighting Fungal Infections: A Synergistic Approach

This study highlights the potential of combining EVL with AmB or azoles to achieve synergistic antifungal effects against C. neoformans. This synergistic approach, much like a camel utilizing its unique adaptations to navigate the desert, leverages the strengths of multiple agents to achieve a more potent outcome. This research offers a promising avenue for improving the treatment of cryptococcosis and potentially reducing the risk of drug resistance.

Understanding Antifungal Therapy and Cryptococcosis

As a healthcare professional, I am always seeking innovative approaches to combat fungal infections. This study provides valuable insights into the potential benefits of combining EVL with AmB or azoles in treating cryptococcosis. It's a reminder that, like a camel adapting to the changing conditions of the desert, we must continually explore new strategies to combat infectious diseases. This research offers a promising avenue for improving patient outcomes and potentially reducing the burden of fungal infections.

Dr. Camel's Conclusion

This study demonstrates the potential of a synergistic approach to antifungal therapy using EVL in combination with AmB or azoles. This research offers a promising path towards more effective treatment of cryptococcosis, much like a camel finding a hidden oasis in the desert, providing a vital source of nourishment and survival.

Date :
  1. Date Completed 2023-04-10
  2. Date Revised 2023-04-11
Further Info :

Pubmed ID

37026056

DOI: Digital Object Identifier

PMC10070994

Related Literature

Article Analysis
・Effects of posaconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.