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Effects of GBT1118, a voxelotor analog, on intestinal pathophysiology in sickle cell disease.

Author: DuttaDibyendu, HarounElio, LimSeah H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study used GBT1118, an analog of voxelotor, to treat Townes sickle cell disease (SCD) mice. GBT1118 improved intestinal pathophysiology, including small intestinal barrier function, microbial density, enterocyte injury, and spleen size. These improvements were associated with increased expression of genes encoding enterocyte tight junction proteins and antimicrobial peptides.
Paper Details　
Original Abstract of the Article :
Voxelotor is an allosteric haemoglobin (Hb) modulator that binds covalently and reversibly to Hb alpha chain to facilitate improved Hb-O<sub>2</sub> affinity and arterial oxygen. It, therefore, reduces the susceptibility of erythrocytes carrying Haemoglobin S to sickle. In this study, we have used G...See full text at original site
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引用元：
https://doi.org/10.1111/bjh.18813

データ提供：米国国立医学図書館（NLM）

GBT1118: A Potential Treatment for Sickle Cell Disease

Sickle cell disease, a complex and challenging condition, often presents a vast desert of difficulties for patients. This study, much like a camel seeking a hidden oasis, explores the potential benefits of GBT1118, an analog of voxelotor, as a treatment for sickle cell disease. The study investigates the impact of GBT1118 on intestinal pathophysiology in mice with sickle cell disease, seeking to alleviate the debilitating symptoms and improve overall health.

GBT1118's Effects on Intestinal Pathophysiology

This study, much like a careful examination of a desert ecosystem, reveals the potential for GBT1118 to improve intestinal health in mice with sickle cell disease. The study found that GBT1118 treatment resulted in improved intestinal barrier function, reduced intestinal microbial density, and reduced enterocyte injury, suggesting that this compound could potentially alleviate the intestinal complications associated with sickle cell disease.

Implications for Sickle Cell Disease Treatment

This study offers a beacon of hope for patients navigating the challenges of sickle cell disease. The study's findings suggest that GBT1118 might offer a potential new treatment strategy to address the intestinal complications associated with sickle cell disease, paving the way for improved health and quality of life for patients. This research underscores the importance of exploring new and innovative treatments for sickle cell disease, seeking to develop effective therapies that address the diverse needs of patients.

Dr.Camel's Conclusion

This research explores the potential benefits of GBT1118, an analog of voxelotor, as a treatment for sickle cell disease. The study's findings highlight the potential of GBT1118 to improve intestinal health in mice with sickle cell disease, offering a glimmer of hope for the development of new and effective treatments for this challenging condition.

Date :
  1. Date Completed 2023-06-27
  2. Date Revised 2023-06-27
Further Info :

Pubmed ID

37052197

DOI: Digital Object Identifier

10.1111/bjh.18813

Related Literature

Article Analysis
・Effects of voxelotor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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