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BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality.

Author: MuraiJunko, PommierYves

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Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
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Overview

BRCAness, a concept describing tumors with deficiencies in homologous recombination repair (HRR), can be identified through genomic profiling. This review explores how BRCAness can be used to select appropriate therapies, including PARP inhibitors, topoisomerase I inhibitors, and platinum derivatives.
Paper Details　
Original Abstract of the Article :
The concept of "BRCAness" was first described in 2004 to define the situation in which a homologous recombination repair (HRR) defect in a tumor relates to and phenocopies BRCA1 or BRCA2 loss-of-function mutations. Soon after the discovery of synthetic lethality of PARP1/2 inhibitors in BRCA1- or BR...See full text at original site
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引用元：
https://doi.org/10.1158/0008-5472.CAN-23-0628

データ提供：米国国立医学図書館（NLM）

BRCAness and Homologous Recombination Deficiency: New Targets for Cancer Therapy

This article explores the concept of 'BRCAness,' a term used to describe the functional loss of BRCA1 or BRCA2 genes in tumor cells, which can occur through various mechanisms. The authors discuss how genomic profiling can identify BRCAness and other homologous recombination deficiency (HRD) genes, leading to personalized cancer therapy. Specifically, they emphasize the potential of using PARP inhibitors, TOP1 inhibitors, and platinum derivatives to target BRCAness/HRD in cancer cells.

Precision Cancer Treatment: Targeting BRCAness and Homologous Recombination Deficiency

The concept of BRCAness and HRD has revolutionized cancer therapy by opening up new avenues for precision medicine. By identifying BRCAness/HRD genes in tumor cells, healthcare providers can tailor treatment strategies to target these specific vulnerabilities. This approach offers the potential for more effective and less toxic treatments, ultimately improving patient outcomes.

Unlocking the Potential of Targeted Therapies for Cancer

The study highlights the potential of targeting BRCAness/HRD in cancer cells, opening up new avenues for personalized cancer treatment. By using PARP inhibitors, TOP1 inhibitors, and platinum derivatives, healthcare providers can effectively target these vulnerabilities, leading to more effective and less toxic treatments. This advancement in cancer therapy offers hope for a future where patients receive individualized treatment strategies tailored to their specific needs.

Dr. Camel's Conclusion

This article provides a comprehensive overview of BRCAness and HRD, two critical concepts in precision cancer treatment. By understanding these concepts, healthcare providers can develop more effective and personalized treatment strategies for cancer patients. Just as a desert explorer navigates by understanding the landscape, doctors can now navigate cancer treatment with a greater understanding of the genetic makeup of tumors, leading to more targeted and effective therapies.

Date :
  1. Date Completed 2023-04-17
  2. Date Revised 2023-04-30
Further Info :

Pubmed ID

37057596

DOI: Digital Object Identifier

10.1158/0008-5472.CAN-23-0628

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Languages

English

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