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Safety profile of clobazam in the real world: an analysis of FAERS database and systematic review of case reports.

Author: AnPengjiao, LiuXin, ZhangBo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed the FDA Adverse Event Reporting System database and case reports to evaluate the safety profile of clobazam. The study found that the most common adverse drug reactions were related to the nervous system, with a high incidence of drowsiness, dizziness, and fatigue. The study also identified a risk of severe skin reactions and potential interactions with other drugs. The study concluded that healthcare providers should be aware of the potential risks associated with clobazam and monitor patients closely for adverse events.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Most of the safety data of clobazam came from well-designed clinical trials, while the real-world information is insufficient. RESEARCH DESIGN AND METHODS: We performed a disproportionality analysis of the FDA Adverse Event Reporting System (FAERS) database through OpenVigil 2 and condu...See full text at original site
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引用元：
https://doi.org/10.1080/14740338.2023.2204227

データ提供：米国国立医学図書館（NLM）

Unveiling the Real-World Safety Profile of Clobazam

This research examines the real-world safety profile of clobazam, a medication used to treat seizures. Think of it like a traveler exploring a new desert landscape – it's important to be aware of the potential dangers that might lie ahead. The researchers delved into the FDA Adverse Event Reporting System (FAERS) database and conducted a systematic review of case reports to assess the drug's safety beyond the controlled environment of clinical trials.

Navigating the Sands of Adverse Effects

The analysis revealed a number of potential side effects associated with clobazam, including nervous system disorders, skin reactions, and respiratory issues. The researchers emphasize the importance of vigilance and monitoring for these potential complications. It's like navigating a desert with potential hidden dangers – awareness and preparation are crucial.

Clobazam: A Double-Edged Sword

This research highlights the complexity of medication safety. Clobazam can be a valuable tool for managing seizures, but it's important to be aware of the potential risks. The researchers emphasize careful monitoring and a proactive approach to managing any potential side effects. It's like traveling with a double-edged sword – it can be a powerful weapon, but it requires careful handling.

Dr. Camel's Conclusion

This research emphasizes the importance of understanding the full safety profile of medications, even those widely used, and encourages ongoing vigilance and monitoring. It's a reminder that knowledge is power, and awareness can help us navigate the complex world of medication use with greater safety and confidence.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-04-19
Further Info :

Pubmed ID

37070461

DOI: Digital Object Identifier

10.1080/14740338.2023.2204227

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・Side Effects of clobazam
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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