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Evaluation of antinociceptive effect and pharmacological mechanisms of thiocyanoacetamide in rats.

Author: Ben AkachaAzaiez, Ben AliRidha, Ben OthmanAmal, El MayMichèle Véronique

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the antinociceptive effect of thiocyanoacetamide (Thm) in rats exposed to thermal pain stimulus. Thm showed significant antinociceptive activity, more effective than paracetamol or dexamethasone and less than morphine. Pharmacological studies suggest that Thm's mechanism involves adrenergic and serotoninergic systems.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Acute pain is the most common type of pain. The aim of the present work was carried out to study the antinociceptive effect and pharmacological mechanisms of thiocyanoacetamide (Thm) in rats exposed to thermal pain stimulus. MATERIALS AND METHODS: The anti-nociceptive effect of the newly...See full text at original site
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引用元：
https://doi.org/10.1111/papr.13234

データ提供：米国国立医学図書館（NLM）

Thiocyanoacetamide: A Potential New Weapon Against Pain

Pain is a universal experience that can significantly impact quality of life. This study investigates the antinociceptive effects of thiocyanoacetamide (Thm), a newly synthesized compound, in rats exposed to thermal pain. The researchers evaluated the effectiveness of Thm in comparison to other analgesics, exploring its potential mechanisms of action.

Thiocyanoacetamide: A Promising Antinociceptive Agent

The study demonstrates that Thm exhibits significant antinociceptive activity in rats, exceeding the effectiveness of paracetamol or dexamethasone and approaching the potency of morphine. The authors identified the involvement of adrenergic and serotoninergic systems in Thm's pain-relieving mechanism. These findings suggest that Thm holds potential as a novel analgesic agent.

A New Oasis in the Desert of Pain: Thiocyanoacetamide Offers Potential Relief

This research provides hope for new and effective treatment options for pain. Thm's unique mechanism of action and impressive antinociceptive activity warrant further investigation into its potential therapeutic applications. Additional studies are needed to fully evaluate its safety and efficacy in clinical settings.

Dr. Camel's Conclusion

The desert of pain can be a desolate and unbearable landscape. Thiocyanoacetamide offers a glimmer of hope, potentially providing a new path to relief. This research reminds us that even in the face of enduring pain, there is always a chance for a brighter future.

Date :
  1. Date Completed 2023-09-05
  2. Date Revised 2023-10-07
Further Info :

Pubmed ID

37083025

DOI: Digital Object Identifier

10.1111/papr.13234

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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