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Sonidegib as a Locally Advanced Basal Cell Carcinoma Therapy in Real-life Clinical Setting: A National Multicentre Study.
Author: Bonfill-OrtíM, Béa-ArdebolS, DezaG, FealC, Fernández-de-MisaR, Ferrandiz-PulidoC, FlorezA, Galiano-MejíasS, Hernández-HernándezN, JakaA, MasferrerE, Mayo-MartinezF, Moreno-ArronesO M, Pérez-PastorG, Rios-BucetaL, Ruiz-SalasV, SanmartinO, TollA, Torres-NavarroI, Turrión-MerinoL, YébenesM
Original Abstract of the Article :
BACKGROUND: Basal cell carcinoma (BCC) is the most prevalent cancer. A minority of BCCs have an aggressive behaviour (laBCC) and may require hedgehog pathway inhibitors such as sonidegib as its treatment. OBJECTIVE: To describe the use of sonidegib in a large number of patients and provide more dat...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ad.2023.04.022
データ提供:米国国立医学図書館(NLM)
Sonidegib: A New Weapon in the Battle Against Basal Cell Carcinoma
In the relentless fight against [basal cell carcinoma (BCC)], [hedgehog pathway inhibitors] have emerged as promising weapons. This study examines the effectiveness of [sonidegib], a hedgehog pathway inhibitor, in a real-world clinical setting. Imagine sonidegib as a sturdy camel, traversing the challenging desert landscape of BCC, seeking to restore balance and defeat the disease.
Sonidegib's Effectiveness in Real-World Clinical Practice
The study, conducted on a cohort of [82 patients], found that sonidegib showed impressive results. Over [81.7%] of patients experienced clinical improvement, with [52.4%] achieving partial response and [29.3%] achieving complete response. This is like seeing a barren desert landscape slowly bloom with life, a testament to sonidegib's effectiveness.
Sonidegib: A Promising Treatment Option with Acceptable Safety
While sonidegib demonstrated its effectiveness, it's important to note that [68.3%] of patients experienced at least one adverse effect, highlighting the need for careful monitoring and individualized treatment plans. Just as a camel must adapt to the harsh desert environment, patients must be carefully monitored for any potential side effects.
Dr. Camel's Conclusion
Sonidegib, like a strong and reliable camel, offers hope to patients battling BCC. Its real-world effectiveness is promising, but as with any treatment, a cautious and personalized approach is crucial. This study serves as a valuable guide, reminding us that the path to defeating BCC requires careful consideration and a collaborative approach between patients and their healthcare providers.
Date :
- Date Completed 2023-07-12
- Date Revised 2023-07-18
Further Info :
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