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Neuroprotective effects of dimethyl fumarate against manic-like behavior induced by ketamine in rats.

Author: AzadnasabReza, KalantarHadi, KhodayarMohammad Javad, SaljoughiShiva

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of dimethyl fumarate (DMF) on ketamine-induced manic-like behavior in rats. DMF was found to prevent hyperlocomotion, reduce oxidative stress, and modulate inflammation in the rat model.
Paper Details　
Original Abstract of the Article :
Medications for treating bipolar disorder (BD) are limited and can cause side effects if used chronically. Therefore, efforts are being made to use new agents in the control and treatment of BD. Considering the antioxidant and anti-inflammatory effects of dimethyl fumarate (DMF), this study was perf...See full text at original site
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引用元：
https://doi.org/10.1007/s00210-023-02505-6

データ提供：米国国立医学図書館（NLM）

Dimethyl Fumarate: A Potential Hope for Bipolar Disorder?

Bipolar disorder is a complex mental illness that affects mood. Current treatments are limited and can have side effects. This study investigates the potential neuroprotective effects of dimethyl fumarate (DMF) on manic-like behavior in rats.

DMF: A Potential Neuroprotective Agent for Bipolar Disorder?

The study demonstrates that DMF has neuroprotective effects, preventing manic-like behavior induced by ketamine in rats. DMF reduced oxidative stress and modulated inflammation in the brain. This research sheds light on the potential therapeutic benefits of DMF for bipolar disorder. This discovery is like finding a hidden spring in the desert, offering a potential new source of hope for individuals struggling with this condition.

Bipolar Disorder: A Complex Condition

Bipolar disorder is a complex condition that requires careful management. This study's findings provide a potential new avenue for treating this condition. It emphasizes the importance of ongoing research to develop more effective and well-tolerated treatments for bipolar disorder. It's a reminder that the journey toward understanding and treating complex mental health conditions is ongoing, like a camel navigating a vast and unforgiving desert.

Dr.Camel's Conclusion

Bipolar disorder is a challenging condition, but research continues to provide promising avenues for treatment. This study's exploration of DMF's potential neuroprotective effects offers a glimmer of hope for the future of bipolar disorder treatment. It's a reminder that the quest for knowledge and better treatments is a continuous journey, like a camel relentlessly traversing a vast and unforgiving desert.
Date :
  1. Date Completed 2023-10-23
  2. Date Revised 2023-10-26
Further Info :

Pubmed ID

37103520

DOI: Digital Object Identifier

10.1007/s00210-023-02505-6

SNS
PICO Info
in preparation
Languages

English

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