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Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy.

Author: AzamiSina, DrewsLisa F, FröhlichJenny, FunkEmilie, GrönkeSebastian, JuricicPaula, LeechThomas, LuJiongming, LuYu-Xuan, NespitalTobias, PartridgeLinda, PaulitzJonathan, ReganJennifer C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of a brief pulse of rapamycin in early adulthood on lifespan and age-related decline in the intestine of female Drosophila and mice. A brief rapamycin treatment in early adulthood extended lifespan and attenuated age-related decline in the intestine in Drosophila to the same degree as lifelong dosing. The study also found that a 3-month early treatment in mice induced a memory effect, with similar maintenance as chronic treatment, of lysozyme distribution, Man2B1 level in intestinal crypts, Paneth cell architecture, and gut barrier function, even 6 months after rapamycin was withdrawn. These findings suggest that brief rapamycin treatments in early adulthood may offer geroprotective benefits without the need for lifelong dosing.
Paper Details　
Original Abstract of the Article :
The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief pulse of the drug in early adulthood in female ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154223/

データ提供：米国国立医学図書館（NLM）

Rapamycin: A Brief Treatment for Long-Lasting Geroprotection?

In the quest for longevity, scientists are exploring the potential of repurposing existing drugs. This study, like a camel caravan searching for a hidden spring of eternal life, explores the geroprotective effects of rapamycin, a drug already used in various medical settings.

Rapamycin: A Short Burst for Long-Term Benefits

The research reveals a fascinating phenomenon: a brief pulse of rapamycin treatment in early adulthood can have long-lasting geroprotective effects in both Drosophila and mice. It's like discovering a single rainfall in the desert that can provide nourishment for years to come. The study identifies the critical role of autophagy, a cellular process that cleans up damaged components, in mediating this effect. It's like understanding how a desert ecosystem relies on the recycling of nutrients to survive.

A Potential Fountain of Youth?

These findings offer a glimmer of hope in the desert of aging research. It's like finding a potential fountain of youth, although further research is needed to translate these findings into practical applications for humans. Understanding the mechanisms behind these effects could lead to novel therapies for extending lifespan and improving health in older individuals.

Dr. Camel's Conclusion

This study, like a trek across the desert, reveals the intriguing possibilities of using rapamycin for geroprotection. It suggests that even short-term interventions can have long-term effects, offering a glimpse into the potential for manipulating the aging process. It's like finding a hidden oasis of knowledge, providing hope for a healthier and longer lifespan.

Date :
  1. Date Completed 2023-05-01
  2. Date Revised 2023-05-07
Further Info :

Pubmed ID

37118497

DOI: Digital Object Identifier

PMC10154223

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English

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