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Telaprevir Treatment Reduces Paralysis in a Mouse Model of Enterovirus D68 Acute Flaccid Myelitis.

Author: ClarkePenny, FrostJoshua, HuYanmei, LeserJ Smith, RudyMichael J, TanHaozhou, TylerKenneth L, WangJun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study investigated the effectiveness of telaprevir, an FDA-approved antiviral, in treating acute flaccid myelitis (AFM) in a murine model of enterovirus D68 (EV-D68) infection. Early treatment with telaprevir improved paralysis outcomes by reducing viral titers and apoptotic activity.
Paper Details　
Original Abstract of the Article :
In 2014, 2016, and 2018, the United States experienced unprecedented spikes in pediatric cases of acute flaccid myelitis (AFM), which is a poliomyelitis-like paralytic illness. Accumulating clinical, immunological, and epidemiological evidence has identified enterovirus D68 (EV-D68) as a major causa...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231134/

データ提供：米国国立医学図書館（NLM）

Telaprevir: A Potential Oasis for Acute Flaccid Myelitis

[Acute flaccid myelitis (AFM)] is a rare but serious neurological condition that can lead to paralysis. This study, like a camel seeking a life-saving oasis in the desert, explores the potential of [telaprevir] as a treatment for AFM caused by [enterovirus D68 (EV-D68)]. The researchers found that early treatment with telaprevir in a mouse model of EV-D68-associated AFM significantly reduced paralysis and improved outcomes. This exciting discovery offers a potential new therapeutic option for AFM.

A Promising Treatment for AFM: A Ray of Hope

The study's findings provide a glimmer of hope for individuals with AFM. The fact that telaprevir, an FDA-approved antiviral drug, showed effectiveness against AFM in a mouse model is very encouraging. This opens the door for further research and potential clinical trials.

Seeking Help and Staying Informed: A Reminder

If you or someone you know is experiencing symptoms of AFM, it's crucial to seek immediate medical attention. Remember that medical research is constantly evolving, and new treatments are being developed.

Dr.Camel's Conclusion

This research, like a refreshing spring in the desert, offers a potential new approach for treating AFM. The study's findings provide hope for a future where individuals with AFM can experience improved outcomes and live healthier lives. As we continue to explore the vast and often challenging desert of neurological research, we may find more effective treatments and cures for diseases like AFM.

Date :
  1. Date Completed 2023-06-02
  2. Date Revised 2023-11-09
Further Info :

Pubmed ID

37154751

DOI: Digital Object Identifier

PMC10231134

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Article Analysis
・Effective treatment of acute flaccid myelitis
SNS
PICO Info
in preparation
Languages

English

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