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Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY-747 designed for the treatment of resistant hypertension.
Author: Becker-PelsterEva-Maria, BrockschniederDamian, FollmannMarkus, HartungIngo V, KnorrAndreas, MondritzkiThomas, RedlichGorden, SandnerPeter, StaschJohannes-Peter, TinelHanna, VakalopoulosAlexandros, WunderFrank
Original Abstract of the Article :
BACKGROUND AND PURPOSE: First-generation soluble guanylate cyclase (sGC) stimulators have shown clinical benefit in pulmonary hypertension (riociguat) and chronic heart failure (vericiguat). However, given the broad therapeutic opportunities for sGC stimulators, tailored molecules for distinct indic...See full text at original site
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引用元：
https://doi.org/10.1111/bph.16142
データ提供：米国国立医学図書館（NLM）
BAY-747: A New Hope for Resistant Hypertension
The ongoing battle against [hypertension] has led to the development of various treatment options, including [soluble guanylate cyclase (sGC) stimulators]. This research focuses on the discovery and characterization of a new generation of sGC stimulator, [BAY-747], specifically designed for the treatment of [resistant hypertension]. The authors highlight the potential of BAY-747 to offer a therapeutic alternative for patients not responding to standard antihypertensive treatments.
A New Generation of sGC Stimulators: Tailored Solutions for Resistant Hypertension
The study found that BAY-747 is a highly potent sGC stimulator both in vitro and in vivo. In experimental models of resistant hypertension, BAY-747 demonstrated a significant and long-lasting decrease in blood pressure. The authors suggest that BAY-747 could be a promising treatment option for patients with hypertension, especially those who have not responded to conventional therapies. This research could pave the way for a more effective approach to treating this complex and prevalent condition.
Embracing a New Frontier in Hypertension Management: Hope for a Healthier Future
This research offers hope for patients battling resistant hypertension. The development of a new generation of sGC stimulators like BAY-747 could represent a significant advancement in the treatment of this condition. Imagine a desert oasis where individuals can access effective therapies, allowing them to manage their hypertension and lead healthier lives. This research paves the way for a future where hypertension management becomes more personalized and effective.
Dr. Camel's Conclusion
This research is like a camel caravan discovering a hidden oasis of hope for individuals struggling with resistant hypertension. The development of BAY-747 represents a significant leap forward in the search for effective treatment options, offering a promising path toward better health and well-being for those affected by this challenging condition.
Date :
- Date Completed 2023-09-05
- Date Revised 2023-09-20
Further Info :
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