An integrated therapeutic approach to sickle cell disease management beyond infancy.

Author: FrangoulHaydar, PollockGalia, RibeilJean-Antoine, SteinbergMartin H

Paper Details 
Original Abstract of the Article :
Hydroxyurea, the first approved drug for sickle cell disease, decreases sickle hemoglobin polymerization by inducing fetal hemoglobin. Its effects in young children are excellent; responses in adults are variable and not curative. The goal of pharmacotherapy should not be disease "moderation" but re...See full text at original site
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引用元:
https://doi.org/10.1002/ajh.26956

データ提供:米国国立医学図書館(NLM)

Sickle Cell Disease: A Holistic Approach to Management

Sickle cell disease is a complex and challenging condition requiring a multi-faceted approach to management. This study presents an integrated therapeutic approach, encompassing hydroxyurea, voxelotor, and crizanlizumab, to address the diverse aspects of the disease and improve patient outcomes. The study emphasizes the importance of addressing both hemolytic anemia and vaso-occlusive events to minimize morbidity and mortality.

Beyond Hydroxyurea: A New Dawn in Treatment

The study explores the potential of combining hydroxyurea with other therapies, such as voxelotor and crizanlizumab, to address the multifaceted nature of sickle cell disease. It emphasizes the need for a more comprehensive and individualized approach to managing the disease. It's like a desert caravan equipped with a diverse range of resources, ready to navigate the challenging terrain of sickle cell disease.

Sickle Cell Disease Management: A Multifaceted Journey

The study highlights the need for personalized treatment strategies for sickle cell disease, considering the individual patient's needs and response to therapy. It emphasizes the importance of ongoing research to develop new and effective treatments, ultimately improving the quality of life for patients with this challenging condition. It's a continuous journey towards a healthier future for patients with sickle cell disease, requiring collaboration, innovation, and unwavering dedication.

Dr.Camel's Conclusion

This study underscores the importance of an integrated therapeutic approach to managing sickle cell disease. The authors propose a multi-faceted strategy that addresses both hemolytic anemia and vaso-occlusive events, offering a more holistic and personalized approach to care. It's a testament to the ongoing efforts to navigate the challenging landscape of sickle cell disease, seeking new oases of hope and better treatment options.
Date :
  1. Date Completed 2023-06-14
  2. Date Revised 2023-06-20
Further Info :

Pubmed ID

37170801

DOI: Digital Object Identifier

10.1002/ajh.26956

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Article Analysis
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in preparation
Languages

English

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