Paper Details

  1. Home
  2. Paper Details

RapaCaspase-9-based suicide gene applied to the safety of IL-1RAP CAR-T cells.

Author: BouquetLucie, Bôle-RichardElodie, DeschampsMarina, FerrandChristophe, GeninDelphine, HaderbacheRafik, Neto Da RochaMathieu, NicodClémentine, TradRim, WardaWalid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This abstract discusses the development of a new medical drug candidate, a chimeric antigen receptor (CAR) targeting interleukin-1 receptor accessory protein (IL-1RAP), and the use of inducible suicide genes to manage potential side effects.
Paper Details　
Original Abstract of the Article :
Even if adoptive cell transfer (ACT) has already shown great clinical efficiency in different types of disease, such as cancer, some adverse events consistently occur, and suicide genes are an interesting system to manage these events. Our team developed a new medical drug candidate, a chimeric anti...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10506905/

データ提供：米国国立医学図書館（NLM）

RapaCaspase-9-Based Suicide Gene for CAR-T Cell Therapy

Chimeric antigen receptor (CAR) T cell therapy has shown great promise in cancer treatment, but it can sometimes lead to adverse events. This research investigates the potential of a new suicide gene system, RapaCaspase-9, to enhance the safety of CAR-T cell therapy. The study evaluates the efficiency and safety of two RapaCaspase-9 constructs, RapaCasp9-G and RapaCasp9-A, in gene-modified T cells.

RapaCaspase-9 Shows Promise for Enhancing CAR-T Safety

The study demonstrates the functionality of RapaCaspase-9 in vitro, showing its potential for inducing T cell apoptosis upon activation by rapamycin. This research provides a potential solution for managing adverse events associated with CAR-T cell therapy, improving the safety profile of this promising treatment modality.

Navigating the Desert of Cancer Treatment: A Quest for Safety

This research sheds light on the evolving landscape of cancer treatment. It's like discovering a new oasis in the vast desert of cancer research, offering a potential solution for improving the safety of CAR-T cell therapy.

Dr.Camel's Conclusion

This study underscores the ongoing quest for safer and more effective cancer treatments. It's a testament to the tireless efforts of researchers to find new ways to combat this complex disease. The search for better therapies is a journey through a vast and challenging desert, but the rewards are immense.
Date :
  1. Date Completed 2023-09-20
  2. Date Revised 2023-09-22
Further Info :

Pubmed ID

37173386

DOI: Digital Object Identifier

PMC10506905

Related Literature

Article Analysis
・Side Effects of sirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.