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Monomethyl fumarate prevents alloimmune rejection in mouse heart transplantation by inducing tolerogenic dendritic cells.

Author: CaoYirui, ChenJuntao, CheukYin Celeste, JiaOuyang, LuoYongsheng, WangJina, WangXuanchuan, ZhangYi, ZhuDong, ZhuTongyu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Monomethyl fumarate (MMF) extended the survival time of heart grafts and inhibited dendritic cell (DC) activation in a mouse model of allogeneic heart transplantation. MMF induced tolerogenic DCs in vitro, leading to prolonged cardiac allograft survival, increased regulatory T cells, and decreased T-cell activation. The mechanism involved Nrf2 pathway activation and metabolic reprogramming.
Paper Details　
Original Abstract of the Article :
Dendritic cells (DCs) are important targets for eliciting allograft rejection after transplantation. Previous studies have demonstrated that metabolic reprogramming of DCs can transform their immune functions and induce their differentiation into tolerogenic DCs. In this study, we aim to investigate...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10281873/

データ提供：米国国立医学図書館（NLM）

Monomethyl Fumarate Induces Tolerogenic Dendritic Cells to Prevent Allograft Rejection

This study investigates the protective effects of monomethyl fumarate (MMF) in preventing alloimmune rejection in mouse heart transplantation. Organ transplantation is a complex procedure, like navigating a vast and treacherous desert. The study aims to find ways to improve the success rate of transplantation by preventing immune rejection.

MMF Promotes Tolerance in Heart Transplantation

The study found that MMF prolonged the survival time of heart grafts by inducing tolerogenic dendritic cells (DCs). DCs are immune cells that play a key role in regulating the immune response. MMF essentially acts like a desert guide, leading the immune system towards tolerance instead of rejection. This is a significant finding with implications for improving transplantation outcomes.

A Promising Approach to Immunosuppression

The study suggests that MMF could be a promising new approach to immunosuppression in transplantation. It's like finding a hidden spring in the desert, offering a sustainable source of tolerance and preventing rejection. Further research is needed to determine the effectiveness of MMF in humans.

Dr.Camel's Conclusion

This research offers a promising avenue for preventing allograft rejection in transplantation. MMF's ability to induce tolerogenic DCs is like discovering a hidden oasis in the desert of transplantation, offering a new path towards improved outcomes.

Date :
  1. Date Completed 2023-06-21
  2. Date Revised 2023-07-01
Further Info :

Pubmed ID

37184280

DOI: Digital Object Identifier

PMC10281873

Related Literature

Article Analysis
・Effects of monomethyl fumarate
SNS
PICO Info
in preparation
Languages

English

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