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EV-D68 virus-like particle vaccines elicit cross-clade neutralizing antibodies that inhibit infection and block dissemination.

Author: FisherBrian E, GrahamBarney S, KanekiyoMasaru, KongWing-Pui, KrugPeter W, MascolaJohn R, MorabitoKaitlyn M, MossDaniel L, RuckwardtTracy J, ShiWei, WangLingshu, YangEun Sung

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A virus-like particle (VLP) vaccine against enterovirus D68 (EV-D68) was developed. VLPs elicited neutralizing antibodies against homologous and heterologous EV-D68 subclades, suggesting potential for a broad-spectrum vaccine.
Paper Details　
Original Abstract of the Article :
Enterovirus D68 (EV-D68) causes severe respiratory illness in children and can result in a debilitating paralytic disease known as acute flaccid myelitis. No treatment or vaccine for EV-D68 infection is available. Here, we demonstrate that virus-like particle (VLP) vaccines elicit a protective neutr...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10191429/

データ提供：米国国立医学図書館（NLM）

EV-D68 Virus-like Particle Vaccines: A Promising Approach for Protection

Enterovirus D68 (EV-D68), a virus that can cause severe respiratory illness, is like a desert wind that can bring sudden and severe storms. This study explores the potential of virus-like particle (VLP) vaccines to protect against EV-D68 infection. The researchers investigated the ability of VLP vaccines to elicit neutralizing antibodies that can block viral infection and spread.

VLP Vaccines: A Novel Approach to EV-D68 Protection

The study found that VLP vaccines effectively elicited neutralizing antibodies against both homologous and heterologous EV-D68 subclades, demonstrating the potential for broad protection. Furthermore, the researchers explored the role of adjuvants, substances that enhance the immune response, in maximizing the effectiveness of the vaccines. They found that a carbomer-based adjuvant, Adjuplex, effectively elicited a balanced immune response, further boosting the protective effect of the vaccines.

Hope for Preventing EV-D68 Infections

This research offers hope for the development of effective vaccines to prevent EV-D68 infections. The promising results with VLP vaccines highlight the potential for a new strategy to combat this challenging virus. This study represents a significant step forward in the fight against EV-D68, offering a glimmer of hope for protecting individuals from the potential risks of this virus.

Dr. Camel's Conclusion

EV-D68 can be a formidable opponent, but this research provides encouraging insights into the potential of VLP vaccines for protection. The findings highlight the importance of ongoing research to develop effective vaccines that can shield individuals from the potential threat of this virus. Just as a camel adapts to the harsh desert environment, scientists are adapting their strategies to combat emerging threats like EV-D68, forging new paths to ensure health and well-being.

Date :
  1. Date Completed 2023-05-19
  2. Date Revised 2023-06-15
Further Info :

Pubmed ID

37196074

DOI: Digital Object Identifier

PMC10191429

SNS
PICO Info
in preparation
Languages

English

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