Pharmacodynamics and side effects of flecainide acetate.

Author: BerryD, ErlienD, GranrudG, HodgesM, KrejciJ, LarsonT, SalernoD M, SharkeyP

Paper Details 
Original Abstract of the Article :
We compared side effects with flecainide trough levels and ECG intervals among 43 patients who received flecainide for up to 34 months. Flecainide plasma levels were higher when associated with cardiovascular side effects (mean 1063 ng/ml; range 296 to 2050 ng/ml) than when no side effects occurred ...See full text at original site
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引用元:
https://doi.org/10.1038/clpt.1986.145

データ提供:米国国立医学図書館(NLM)

Flecainide Acetate: Navigating the Therapeutic-Toxic Window

The world of heart rhythm disorders is complex, with medications like flecainide acetate playing a crucial role in maintaining a steady beat. This study delves into the delicate balance between flecainide's therapeutic benefits and its potential side effects. Researchers meticulously analyzed the relationship between flecainide plasma levels, ECG intervals, and the occurrence of side effects in patients undergoing treatment. The findings offer valuable insights into optimizing flecainide dosage to maximize efficacy while minimizing risks.

Flecainide Dosage: A Balancing Act

The study identified a therapeutic-toxic window for flecainide plasma levels, where the probability of achieving therapeutic effects is high while the risk of cardiovascular side effects remains low. This window serves as a valuable guide for clinicians to tailor dosage to each patient's individual needs. Notably, higher flecainide plasma levels were associated with an increased risk of cardiovascular side effects and greater changes in ECG intervals. This emphasizes the importance of careful monitoring and dose adjustments based on individual patient responses.

Health Implications and Daily Considerations

This study highlights the importance of close monitoring when taking flecainide acetate. While this medication can be effective in treating heart rhythm disorders, it's crucial to be aware of potential side effects and to work closely with your healthcare provider to ensure that your dosage is appropriately adjusted. Regular monitoring and open communication with your doctor will help you navigate the therapeutic journey safely and effectively.

Dr.Camel's Conclusion

Like navigating a sandstorm, managing flecainide therapy requires careful attention to detail. This study underscores the critical importance of understanding the drug's therapeutic-toxic window and its impact on ECG intervals to ensure safe and effective treatment. By working closely with your healthcare provider, you can navigate the complexities of flecainide therapy, reaching your destination with a steady beat.

Date :
  1. Date Completed 1986-08-08
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

3720173

DOI: Digital Object Identifier

10.1038/clpt.1986.145

Related Literature

SNS
PICO Info
in preparation
Languages

English

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