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Pharmacokinetics and Safety of Coadministered Atogepant and Topiramate in Healthy Participants: A Phase 1, Open-Label, Drug-Drug Interaction Study.

Author: BoinpallyRamesh, BorbridgeLisa, McGeeneyDanielle, TrugmanJoel

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This open-label, single-center, 2-cohort, phase 1 trial evaluated the potential pharmacokinetic (PK) 2-way drug-drug interactions (DDIs), safety, and tolerability of atogepant and topiramate in healthy adults. The 25% reduction in atogepant exposure when coadministered with topiramate is not considered to be clinically relevant and would not require dose adjustments.
Paper Details　
Original Abstract of the Article :
Atogepant, an oral calcitonin gene-related peptide receptor antagonist, and topiramate, a commonly used oral antiepileptic, are approved as preventive migraine treatments. Given the distinct mechanisms of action of these treatments, it is possible that they may be coprescribed for migraine. This ope...See full text at original site
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引用元：
https://doi.org/10.1002/cpdd.1267

データ提供：米国国立医学図書館（NLM）

Atogepant and Topiramate: A Search for a New Oasis in the Desert of Migraine Treatment

The desert of migraine treatment is a landscape of ongoing research and development, seeking new and effective solutions to alleviate pain and improve quality of life. This study explores the potential pharmacokinetic (PK) interactions between atogepant, a calcitonin gene-related peptide receptor antagonist, and topiramate, a commonly used antiepileptic drug, both approved as preventive migraine treatments. Researchers conducted a phase 1, open-label, drug-drug interaction study to assess the safety and tolerability of coadministering atogepant and topiramate in healthy adults. Their findings indicate that while coadministration does lead to a slight reduction in atogepant exposure, this reduction is not considered clinically significant and does not require dose adjustments. This research provides a valuable assessment of the potential for co-prescribing atogepant and topiramate, offering insights into their combined safety and effectiveness.

A Promising Oasis: Coadministration of Atogepant and Topiramate

This study suggests that co-prescribing atogepant and topiramate may be a viable option for migraine prevention. It's like finding a new oasis in the desert, offering a combined approach to managing this debilitating condition.

Navigating the Desert of Migraine: Practical Implications for Everyday Life

This research highlights the importance of consulting with a healthcare professional to determine the most appropriate migraine treatment strategy for your individual needs. It's crucial to discuss any potential drug interactions and ensure safe and effective medication use.

Dr.Camel's Conclusion

This study provides a promising exploration of the potential for coadministering atogepant and topiramate for migraine prevention. It offers a glimmer of hope in the desert of migraine treatment, suggesting that this combination may provide a valuable new option for managing this common condition.

Date :
  1. Date Completed 2023-10-04
  2. Date Revised 2023-10-05
Further Info :

Pubmed ID

37210713

DOI: Digital Object Identifier

10.1002/cpdd.1267

Related Literature

Article Analysis
・Effects of atogepant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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