Impact of weight gain with dolutegravir on antiretroviral adherence and viral suppression in four African countries.

Author: , AkeJulie A, BahemanaEmmanuel, CavanaughJ Sean, CrowellTrevor A, EsberAllahna L, IroezinduMichael, KibuukaHannah, MaswaiJonah, OwuothJohn, RomoMatthew L, ShahNeha, Sing'oeiValentine

Paper Details 
Original Abstract of the Article :
OBJECTIVE: We hypothesized that total body weight (TBW) gain after switching antiretroviral therapy (ART) regimen to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) may negatively impact ART adherence and viral load (VL) and therefore sought to examine these associations. METHODS: The o...See full text at original site
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引用元:
https://doi.org/10.1111/hiv.13501

データ提供:米国国立医学図書館(NLM)

Weight Gain and Antiretroviral Adherence in HIV Patients

The world of [HIV] treatment is constantly evolving, with new drugs and therapies emerging. This study delves into the impact of weight gain after switching to a new antiretroviral regimen, specifically [tenofovir disoproxil fumarate/lamivudine/dolutegravir], on [antiretroviral adherence] and [viral suppression].

Researchers analyzed data from the [AFRICOS] cohort study, which included participants from four African countries. They observed that a significant proportion of patients experienced weight gain after switching to [TLD], particularly females and those transitioning from [efavirenz] to [TLD]. However, the study found no significant association between weight gain and changes in [ART adherence] or [viral load].

Weight Gain: Not Always a Cause for Concern

The study's results suggest that weight gain after switching to [TLD] may not necessarily lead to decreased adherence or viral suppression. This finding is encouraging, as it alleviates concerns about potential negative consequences associated with weight gain in [HIV] patients.

Staying on Course in the Journey of HIV Treatment

While the study's results provide some reassurance, it's crucial for [HIV] patients to maintain open communication with their healthcare providers. Weight changes can be a sign of various health issues, and regular monitoring is essential. Remember that staying on track with treatment and maintaining a healthy lifestyle are vital in managing this complex condition.

Dr.Camel's Conclusion

Just as a camel adapts to the harsh desert environment, [HIV] patients are constantly adjusting to the challenges of their condition. This study reminds us that weight gain doesn't always signal a setback in treatment. By staying vigilant and working closely with healthcare professionals, we can navigate the journey of [HIV] treatment with confidence and optimism.

Date :
  1. Date Completed 2023-10-23
  2. Date Revised 2023-10-23
Further Info :

Pubmed ID

37232057

DOI: Digital Object Identifier

10.1111/hiv.13501

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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