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Germline BRCA-Mutated HER2-Negative Advanced Breast Cancer: Overcoming Challenges in Genetic Testing and Clinical Considerations When Using Talazoparib.

Author: BrugioniEmily, Cathcart-RakeElizabeth, DouglassLindsey, GustafsonElizabeth, MetskerJanie, PluardTimothy J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Genetic testing for BRCA1/2 mutations is crucial for the diagnosis and treatment of breast cancer. It helps identify patients at increased risk and those eligible for PARP inhibitor therapy. This article highlights the importance of genetic testing, challenges in access, and a case study illustrating the clinical considerations of talazoparib in a patient with germline BRCA-mutated HER2-negative metastatic breast cancer.
Paper Details　
Original Abstract of the Article :
Genetic testing is essential to the diagnosis and management of patients with breast cancer. For example, women who carry mutations in BRCA1/2 genes have an increased lifetime risk of breast cancer and the presence of these mutations may sensitize the patient to treatment with poly(ADP-ribose) polym...See full text at original site
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引用元：
https://doi.org/10.1016/j.clbc.2023.04.006

データ提供：米国国立医学図書館（NLM）

Genetic Testing for Breast Cancer: Navigating the Complexities

Imagine a vast desert landscape, where each dune represents a different gene. Some dunes are stable and unchanging, while others are prone to shifting and instability. This study examines the role of genetic testing in the diagnosis and management of breast cancer, focusing on the BRCA1/2 genes, known for their role in increasing breast cancer risk. The study explores the importance of genetic testing for women with advanced breast cancer and the potential benefits of PARP inhibitors, a class of drugs that target specific genetic mutations.

The Importance of Genetic Testing in Breast Cancer

The study emphasizes the critical role of genetic testing in identifying women who may benefit from PARP inhibitors. It highlights the challenges faced by patients and clinicians in accessing genetic testing, urging for increased awareness and accessibility. The study also provides a case study to illustrate the clinical considerations involved in using talazoparib, a specific PARP inhibitor, for women with BRCA-mutated breast cancer.

Understanding and Managing Advanced Breast Cancer

This research underscores the importance of personalized medicine in treating advanced breast cancer. It highlights the need for a multidisciplinary approach to managing patients, involving specialists from various disciplines to ensure comprehensive care. It also emphasizes the importance of patient-centered decision-making, allowing women to be actively involved in their treatment plans.

Dr.Camel's Conclusion

This study emphasizes the critical role of genetic testing in tailoring treatment strategies for women with advanced breast cancer. It highlights the importance of ensuring access to genetic testing and the potential benefits of PARP inhibitors for women with BRCA-mutated breast cancer. It also reinforces the need for a comprehensive, multidisciplinary approach to managing this complex disease.

Date :
  1. Date Completed 2023-06-21
  2. Date Revised 2023-06-22
Further Info :

Pubmed ID

37246120

DOI: Digital Object Identifier

10.1016/j.clbc.2023.04.006

Related Literature

Article Analysis
・Side Effects of talazoparib
SNS
PICO Info
in preparation
Languages

English

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