Cognitive effects of individual anticholinergic drugs: a systematic review and meta-analysis.

Author: HajebrahimiSakineh, HosseiniMohammad-Salar, NaseriAmirreza, Sadigh-EteghadSaeed, Salehi-PourmehrHanieh, Seyedi-SahebariSepideh

Paper Details 
Original Abstract of the Article :
UNLABELLED: Anticholinergics (ACs) are among the most prescribed drugs. Investigating the impaired cognitive domains due to individual ACs usage is associated with controversial findings. OBJECTIVE: The objective of this study was to investigate the effects of individual ACs on different aspects of...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229087/

データ提供:米国国立医学図書館(NLM)

Anticholinergics: Navigating the Cognitive Desert

Anticholinergics (ACs) are a group of medications commonly prescribed for various conditions. While they can provide relief from symptoms, there has been ongoing debate about their potential impact on cognitive function. This study digs deep into the effects of individual anticholinergic drugs on different aspects of cognition, aiming to shed light on these concerns.

This systematic review and meta-analysis, conducted with meticulous attention to detail, analyzed data from multiple clinical trials. The researchers carefully evaluated the impact of individual anticholinergic drugs on various cognitive domains, including memory, attention, and overall cognitive function. The review found that scopolamine, a specific type of anticholinergic, was consistently associated with reduced cognitive performance in various cognitive tasks. However, it's important to note that the quality of the included studies varied, highlighting the need for more robust research in this area.

Anticholinergics and Cognition: A Complex Landscape

This research underscores the importance of careful consideration when prescribing anticholinergics, especially for individuals with cognitive concerns. It suggests that while some anticholinergics may have minimal impact on cognition, others, such as scopolamine, may be associated with cognitive decline. More research is needed to understand the precise effects of different anticholinergic drugs on cognitive function and to develop safer alternatives when necessary.

Navigating the Cognitive Desert: A Call for Caution

This study serves as a reminder of the importance of careful navigation when venturing into the vast desert of cognitive function. While anticholinergics can be valuable tools, we need to proceed with caution, especially when prescribing them for individuals with cognitive vulnerabilities. It is essential to continue researching and developing strategies to minimize potential cognitive side effects while maximizing the benefits of these important medications.

Dr. Camel's Conclusion

The world of cognitive function is a complex desert landscape, where the effects of medications can be subtle and unpredictable. This research provides valuable insights into the potential impacts of anticholinergics on cognition, urging us to tread carefully and prioritize patient well-being. As we continue to explore the intricacies of cognitive function and its interaction with medications, we must ensure that our interventions are informed by robust scientific evidence and a commitment to minimizing potential harm.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-06-04
Further Info :

Pubmed ID

37261256

DOI: Digital Object Identifier

PMC10229087

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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