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Efficacy and safety of sonidegib for the management of basal cell carcinoma: a drug safety evaluation.

Author: FornaroLuigi, GencoLucia, GuerrasioGianluca, LacarrubbaFrancesco, MicaliGiuseppe, PotestioLuca, RuggieroAngelo, ScalvenziMassimiliano, VillaniAlessia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the use of sonidegib, a Hedgehog (HH) pathway inhibitor, for the treatment of locally advanced basal cell carcinoma (laBCC) in patients who are not amenable to surgery or radiation therapy. Sonidegib offers a valuable treatment option for patients with difficult-to-treat BCCs.
Paper Details　
Original Abstract of the Article :
Surgery is the standard management for most of basal cell carcinomas (BBCs). In some cases, also radiotherapy may be a valuable weapon as well as ablative and topical treatments. However, all these approaches may be limited by some tumor features. In this scenario, locally advanced BCCs (laBCC) and ...See full text at original site
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引用元：
https://doi.org/10.1080/14740338.2023.2227089

データ提供：米国国立医学図書館（NLM）

Sonidegib: A Camel's Guide to Treating Basal Cell Carcinoma

The realm of [Basal Cell Carcinoma (BCC)] is a challenging one, marked by the relentless growth of cancerous cells. The goal of treatment is to effectively manage BCC, and recent advancements in [Targeted Therapies] have led to the development of new drugs like [Sonidegib]. This study delves into the efficacy and safety of sonidegib in managing BCC. It's like discovering a new oasis in the vast desert of cancer treatment, offering a fresh perspective on how to manage this challenging condition.

A New Oasis: A Camel's Perspective on Sonidegib

The researchers highlight the use of sonidegib for managing [Locally Advanced BCC (laBCC)] and [Metastatic BCC]. Sonidegib works by inhibiting the [Hedgehog (HH) pathway], a key signaling pathway involved in BCC development. It's like finding a hidden spring in the desert that can help quench the thirst of cancerous cells. By targeting this specific pathway, sonidegib offers a new avenue for treating these difficult-to-treat forms of BCC.

A Promising Solution: A Camel's Advice for BCC Treatment

Sonidegib, along with other targeted therapies, represents a significant advancement in BCC treatment. By understanding the intricacies of the HH pathway and developing drugs that specifically target it, we can potentially improve the lives of patients with BCC. This study, like a beacon in the desert, points to the promise of targeted therapies in managing this challenging condition.

Dr. Camel's Conclusion

This study is a reminder that we are constantly discovering new ways to combat cancer. By diligently exploring the vast desert of medical research, we can uncover valuable new treatments, like sonidegib, that offer hope for patients with BCC. This discovery is a testament to the resilience and resourcefulness of the scientific community, and it paves the way for even more effective and personalized treatments in the future.

Date :
  1. Date Completed 2023-11-02
  2. Date Revised 2023-11-02
Further Info :

Pubmed ID

37326221

DOI: Digital Object Identifier

10.1080/14740338.2023.2227089

Related Literature

Article Analysis
・Effects of sonidegib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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