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Development of a sustained release implant of benzathine penicillin G for secondary prophylaxis of rheumatic heart disease.

Author: BarberBryce W, BarrRenae K, BattyKevin T, BoydBen J, CarapetisJonathan R, KadoJoseph, LandersdorferCornelia B, ManningLaurens, MuskGabrielle C, Page-SharpMadhu, SalmanSam, TaitJessica R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Intramuscular benzathine penicillin G (BPG) injections are the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis, but adherence is poor. An implant that provides sustained penicillin concentrations for more than six months is needed to improve adherence.
Paper Details　
Original Abstract of the Article :
Regular intramuscular (i.m.) benzathine penicillin G (BPG) injections have been the cornerstone of rheumatic heart disease (RHD) secondary prophylaxis since the 1950s. Patient adherence to IM BPG is poor, largely due to pain, the need for regular injections every 3-4 weeks and health sector delivery...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2023.06.006

データ提供：米国国立医学図書館（NLM）

A New Hope for Rheumatic Heart Disease: A Sustained Release Implant of Benzathine Penicillin G

Rheumatic heart disease (RHD) is a serious health concern, and finding effective ways to prevent it is a top priority. This study, published in [journal name], presents a promising new approach to RHD secondary prophylaxis, exploring the development of a sustained-release implant of benzathine penicillin G (BPG).

The authors highlight the challenges associated with the current standard of care, which relies on regular intramuscular (i.m.) injections of BPG. These injections can be painful, inconvenient, and require frequent visits to healthcare providers. The authors propose a novel solution: a sustained-release implant that could provide continuous penicillin levels for up to 6 months.

The study describes the development and preclinical testing of this novel implant. The authors demonstrate that the implant can provide sustained levels of penicillin, potentially eliminating the need for frequent injections and improving patient adherence to treatment.

A New Era for RHD Prophylaxis: A More Convenient and Effective Approach

The study's findings represent a significant advancement in the treatment of RHD. The development of a sustained-release implant for BPG could revolutionize RHD prophylaxis, making treatment more convenient and effective for patients.

The Power of Innovation: A Beacon in the Desert of Disease

This study is a testament to the power of innovation in medicine. The development of this novel implant offers a promising new approach to RHD prophylaxis, potentially improving the lives of countless patients worldwide.

Dr. Camel's Conclusion

This study, like a refreshing oasis in the desert of RHD research, offers a new hope for patients seeking effective treatment. The development of a sustained-release implant for BPG is a beacon of progress, promising a more convenient and effective way to prevent this debilitating condition.

Date :
  1. Date Completed 2023-07-24
  2. Date Revised 2023-07-24
Further Info :

Pubmed ID

37354997

DOI: Digital Object Identifier

10.1016/j.ejpb.2023.06.006

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PICO Info
in preparation
Languages

English

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