Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations.

Author: AhmadzadehShahab, BabinCaroline P, BlakeJames C, CatalanoNicole T, KayeAlan D, PearlNathan Z, ShekoohiSahar

Paper Details 
Original Abstract of the Article :
Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies. One drug that is now being used for a variety of conditions is topiramate. This is a narrative review that used PubMed, Google Scholar, MEDLINE, and Scie...See full text at original site
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引用元:
https://doi.org/10.1007/s12325-023-02586-y

データ提供:米国国立医学図書館(NLM)

Topiramate: A Multifaceted Oasis in the Desert of Neurological Conditions

Greetings from Dr. Camel, your guide through the intricate desert of neurological conditions. This narrative review explores the diverse clinical uses and pharmacological considerations of topiramate, a widely prescribed second-generation antiseizure drug. Topiramate is a truly remarkable compound, offering a unique combination of therapeutic benefits. It's like a multi-faceted oasis in the desert, capable of providing relief for a range of neurological challenges.

Topiramate: A Versatile Tool for Neurological Relief

Topiramate has earned a reputation for its versatility, proving effective in the treatment of epilepsy, migraine prophylaxis, and even weight loss. The drug works by modulating multiple pathways in the brain, including blocking sodium and calcium channels, inhibiting glutamate receptors, enhancing GABA receptors, and inhibiting carbonic anhydrase. This multi-pronged approach makes topiramate a powerful tool for managing neurological disorders. It's like a skilled desert nomad, equipped with a diverse set of tools for navigating the challenges of the landscape.

Navigating the Side Effects: Finding Balance in the Desert

While topiramate offers numerous benefits, it's crucial to be aware of its potential side effects. Commonly reported side effects include paresthesia, confusion, fatigue, dizziness, and changes in taste. In some cases, more serious adverse effects may occur, such as acute glaucoma, metabolic acidosis, nephrolithiasis, hepatotoxicity, and teratogenicity. Just like a traveler in the desert, it's essential to be prepared for the challenges that may arise and to seek appropriate guidance when needed.

Dr. Camel's Conclusion

Topiramate is a valuable tool for managing a variety of neurological conditions. Its versatility and effectiveness make it a valuable asset in the desert of neurological treatment. However, it's crucial to be aware of its potential side effects and to work closely with healthcare professionals to ensure its safe and effective use. By understanding both the benefits and risks, we can harness the power of this unique oasis in the desert of neurological health.

Date :
  1. Date Completed 2023-08-16
  2. Date Revised 2023-10-07
Further Info :

Pubmed ID

37368102

DOI: Digital Object Identifier

10.1007/s12325-023-02586-y

Related Literature

SNS
PICO Info
in preparation
Languages

English

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