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Safety and Efficacy of Trifluridine/Tipiracil Administered After Anti-PD-1 Therapies for Advanced Gastric Cancer.

Author: DemachiKen, KawazoeAkihito, KotaniDaisuke, NakamuraHitomi, OkunakaMashiro, ShitaraKohei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A retrospective review of 60 patients with advanced gastric cancer (AGC) who received trifluridine/tipiracil monotherapy as a third- or later-line chemotherapy found that the treatment was well-tolerated and demonstrated anti-tumor activity in patients with or without previous anti-PD-1 therapies.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIM: The phase III TAGS trial of trifluridine/tipiracil showed a survival benefit compared with placebo as a third- or later-line treatment in patients with advanced gastric cancer (AGC), in which only a few patients had a history of previous treatment with immune checkpoint inhibitors. ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347914/

データ提供：米国国立医学図書館（NLM）

Trifluridine/Tipiracil: A Promising Treatment Option for Advanced Gastric Cancer

This retrospective study investigates the safety and efficacy of trifluridine/tipiracil, a chemotherapy regimen, as a third- or later-line treatment for advanced gastric cancer (AGC). The research explores the use of this regimen in patients who have previously received anti-PD-1 therapies, evaluating its effectiveness and potential side effects. The study found that trifluridine/tipiracil was well-tolerated and demonstrated anti-tumor activity in this challenging patient population.

Combating Gastric Cancer: Seeking Solutions for Advanced Stages

This research highlights the challenges of treating advanced gastric cancer, a complex and often aggressive disease. Just as a camel faces obstacles while crossing the vast desert, researchers must navigate the complexities of cancer treatment to find effective solutions. The study's findings offer a glimmer of hope for patients with advanced gastric cancer, suggesting that trifluridine/tipiracil could be a viable treatment option.

Gastric Cancer: A Journey Towards Improved Outcomes

This research encourages continued research into the treatment of gastric cancer, particularly in advanced stages. The study highlights the need for personalized approaches to treatment, considering the individual patient's medical history and the potential benefits and risks of different therapies. The research underscores the importance of developing innovative treatments to improve outcomes for patients with advanced gastric cancer.

Dr. Camel's Conclusion

This retrospective study explores the safety and efficacy of trifluridine/tipiracil as a treatment option for advanced gastric cancer, particularly in patients who have previously received anti-PD-1 therapies. The study's findings suggest that this chemotherapy regimen could be a viable treatment option, offering hope for patients with this challenging disease.
Date :
  1. Date Completed 2023-06-29
  2. Date Revised 2023-07-16
Further Info :

Pubmed ID

37369502

DOI: Digital Object Identifier

PMC10347914

Related Literature

Article Analysis
・Effects of trifluridine and tipiracil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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