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GPER1 deficiency causes sex-specific dysregulation of hippocampal plasticity and cognitive function.

Author: BenderRoland A, KarstenYannik, KoitmäeAune, LiXiaoyu, MorelliniFabio, RuneGabriele M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study provides evidence for sex-specific roles of GPER1 in hippocampus-related learning and memory. GPER1-KO males showed reduced anxiety, whereas the fear response was specifically increased in GPER1-KO females. Spatial learning and memory consolidation was impaired by GPER1 deficiency in both sexes. The study found that excitability at Schaffer collateral synapses in CA1 increased in GPER1-deficient males and in proestrus/diestrus females, concordant with an increased hippocampal expression of the AMPA-receptor subunit GluA1 in GPER1-KO males and females. Dysregulation of GPER1 functions may underlie sex-specific cognitive deficits or mood disorders.
Paper Details　
Original Abstract of the Article :
Estrogens regulate synaptic properties and influence hippocampus-related learning and memory via estrogen receptors, which include the G-protein-coupled estrogen receptor 1 (GPER1). Studying mice, in which the GPER1 gene is dysfunctional (GPER1-KO), we here provide evidence for sex-specific roles of...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/37399525

データ提供：米国国立医学図書館（NLM）

GPER1: A Sex-Specific Regulator of Hippocampal Plasticity

The desert of the brain is a complex landscape, and understanding the mechanisms that regulate brain function is a constant challenge. This study investigates the role of GPER1, a type of estrogen receptor, in hippocampal plasticity, which is the brain's ability to adapt and change. The researchers found that GPER1 deficiency led to sex-specific changes in hippocampal plasticity and cognitive function, with males showing reduced anxiety and females exhibiting increased fear responses.

Furthermore, both sexes showed impairments in spatial learning and memory consolidation. The researchers also observed sex-specific changes in hippocampal excitability and the expression of key proteins involved in synaptic function. These findings highlight the complex and sex-specific roles of GPER1 in brain function.

A Sex-Specific Journey: Exploring GPER1's Role in the Brain

This study underscores the importance of considering sex differences in brain function and disease. The research highlights the complex and sex-specific roles of GPER1 in regulating hippocampal plasticity and cognitive function.

A Camel's Perspective on Brain Health: The Importance of Understanding Sex Differences

This research reminds us that the desert of the brain is a complex landscape, and understanding the nuances of sex differences is crucial for developing effective treatments and therapies. Just as a camel navigates the desert with its keen senses, we must approach brain research with a keen understanding of the intricacies of sex-specific differences.

Dr. Camel's Conclusion

This study takes us on a fascinating journey through the desert of the brain, revealing the intricate and sex-specific roles of GPER1. It emphasizes the importance of understanding these differences for developing personalized treatments and therapies. Just as a camel navigates the desert with its unique adaptations, we must continue to explore the intricacies of the brain with a focus on individual variations and the impact of sex differences.

Date :
  1. Date Completed 2023-08-03
  2. Date Revised 2023-08-04
Further Info :

Pubmed ID

37399525

DOI: Digital Object Identifier

JOE-22-0204

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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