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Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility.

Author: DickensheetsHarold, DonnellyRaymond P, HickersonBrady T, IlyushinaNatalia A, InceWilliam L, PetrovskayaSvetlana N

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study investigated the impact of the proportion of drug-resistant subpopulations on the ability to detect resistance in clinical isolates and the impact of substitutions on viral replication of mixtures containing both drug-sensitive and drug-resistant variants. The findings highlight the potential impact of baloxavir-resistant substitutions on baloxavir susceptibility and other biological properties of influenza virus.
Paper Details　
Original Abstract of the Article :
Baloxavir marboxil (baloxavir) is a recently FDA-approved influenza virus polymerase acidic (PA) endonuclease inhibitor. Several PA substitutions have been demonstrated to confer reduced susceptibility to baloxavir; however, their impacts on measurements of antiviral drug susceptibility and replicat...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373543/

データ提供：米国国立医学図書館（NLM）

Fighting Influenza: A Battle Against Resistance

The fight against influenza is like a constant battle against a shifting desert landscape. This research focuses on the emergence of resistance to [baloxavir marboxil (baloxavir)], a promising new antiviral drug. It's like discovering that an oasis we thought was safe has become vulnerable to attack by a new type of desert creature. The authors explore the impact of [PA substitutions] on the susceptibility of influenza viruses to baloxavir.

Resistance to Baloxavir: A Desert of Challenges

This research reveals the challenges posed by [baloxavir-resistant influenza virus variants]. It's like finding that a once-reliable path through the desert is now blocked by shifting sand dunes. The authors examine the impact of [PA substitutions] on viral replication and drug susceptibility, highlighting the importance of understanding and mitigating resistance. This research provides valuable insights into the evolving landscape of influenza and the importance of staying ahead of the curve.

Navigating Influenza Resistance: A Desert of Solutions

This research highlights the importance of developing strategies to combat [baloxavir resistance]. It's like searching for a new route across the desert to bypass the obstacles. The authors propose a combination of [phenotypic assays, droplet digital PCR (ddPCR), and next-generation sequencing (NGS)] to detect and monitor resistant variants. This research underscores the need for vigilant surveillance and proactive measures to ensure effective treatment of influenza infections.

Dr.Camel's Conclusion

The fight against influenza is a constant dance with a changing desert landscape. This research highlights the emergence of [baloxavir resistance] and the importance of developing strategies to overcome this challenge. It's like finding a new oasis in the desert, a haven of hope for future treatments and a reminder of the ongoing battle against this formidable foe.

Date :
  1. Date Completed 2023-08-01
  2. Date Revised 2023-08-01
Further Info :

Pubmed ID

37404185

DOI: Digital Object Identifier

PMC10373543

Related Literature

Article Analysis
・Effects of baloxavir marboxil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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