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Current Treatment Options in Relapsed and Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: a Review.

Author: IslamPrioty

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the current treatment landscape for relapsed and refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL), outlining different therapeutic approaches based on prior therapies and highlighting the importance of clinical trial enrollment for patients with complex disease.
Paper Details　
Original Abstract of the Article :
Treatment of relapsed and refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) has changed dramatically over the past decade due to the development of oral targeted agents in several therapeutic classes, including BTK inhibitors (such as ibrutinib, acalabrutinib, zanubrutin...See full text at original site
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引用元：
https://doi.org/10.1007/s11864-023-01112-0

データ提供：米国国立医学図書館（NLM）

Navigating the Landscape of Chronic Lymphocytic Leukemia

Imagine a camel traversing a vast desert, encountering various obstacles and challenges along the way. The treatment of relapsed and refractory chronic lymphocytic leukemia (CLL) is much like this arduous journey. The landscape of CLL treatment has undergone a significant transformation in recent years with the development of various targeted therapies. This review examines the current treatment options available for patients with R/R CLL, providing a comprehensive guide for navigating this complex disease.

Tailored Treatment Strategies

The author outlines a personalized approach to treatment based on a patient's prior therapies. The use of targeted therapies like BTK inhibitors and BCL2 inhibitors has become crucial in managing R/R CLL. This approach, akin to customizing a camel's load to suit the terrain, allows for individualized treatment strategies to maximize effectiveness and minimize side effects.

Challenges and Future Directions

The review highlights the limitations of current treatment options for patients who have progressed on both BTK and BCL2 inhibitors. This underscores the need for further research and the development of novel therapies for this challenging population. The review also emphasizes the importance of clinical trials for patients with R/R CLL, providing hope for future advancements in treatment.

Dr. Camel's Conclusion

This review offers valuable insights into the current landscape of R/R CLL treatment, highlighting the importance of personalized approaches and the need for ongoing research to develop more effective therapies. It underscores the complexity of this disease and the importance of collaborative efforts to find new and innovative solutions.

Date :
  1. Date Completed 2023-09-05
  2. Date Revised 2023-09-13
Further Info :

Pubmed ID

37407887

DOI: Digital Object Identifier

10.1007/s11864-023-01112-0

SNS
PICO Info
in preparation
Languages

English

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