Evaluation of the pharmacokinetic interactions and safety of atogepant coadministered with esomeprazole.

Author: BoinpallyRamesh, BorbridgeLisa, ButlerMatthew, PapinskaAnna, RojoJonathan, WangsadipuraVeronica

Paper Details 
Original Abstract of the Article :
<b>Aim:</b> To investigate potential pharmacokinetic interactions between atogepant and esomeprazole. <b>Methods:</b> Atogepant, esomeprazole, or both were administered to 32&#160;healthy adults in an open-label, nonrandomized, crossover study. Systemic exposure (area under the plasma concentration...See full text at original site
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引用元:
https://doi.org/10.2217/pmt-2023-0040

データ提供:米国国立医学図書館(NLM)

Atogepant and Esomeprazole: A Harmonious Journey in the Desert of Migraines

Migraines, a debilitating and unpredictable desert storm of pain, often require careful navigation with the right medications. This study investigated potential pharmacokinetic interactions between atogepant, a new treatment for migraines, and esomeprazole, a proton pump inhibitor commonly used to treat heartburn. The researchers, like experienced desert explorers, sought to understand how these medications interact within the body's complex landscape. Their findings, like a carefully planned caravan route, could help ensure the safe and effective delivery of these medications to patients suffering from migraines.

Navigating the Desert: Understanding Drug Interactions

The study found that esomeprazole had no clinically meaningful effect on atogepant pharmacokinetics. This is like discovering that two different paths across the desert, while distinct, can be safely traversed together without interfering with each other. This finding is a reassuring discovery, indicating that these medications can be co-administered without compromising their effectiveness or safety. It's a crucial step towards finding the right combination of medications for those battling migraines.

A Smoother Journey: Harmonious Migraine Treatment

The study's findings offer hope for those suffering from migraines who may also experience heartburn. It's like finding a peaceful oasis where travelers can rest and recover without encountering unexpected storms. The harmonious interaction between atogepant and esomeprazole could lead to a more comfortable and effective treatment journey for patients experiencing both migraines and heartburn, allowing them to navigate the desert of illness with greater ease.

Dr. Camel's Conclusion

The desert of migraines can be a challenging landscape to navigate. This study provides valuable insights into the potential interaction between atogepant and esomeprazole, suggesting a safe and effective combination for those seeking relief from both migraines and heartburn. It's a reminder that ongoing research and exploration in the field of migraine treatment can lead to more harmonious and effective therapies, making the journey through the desert of pain more manageable.

Date :
  1. Date Completed 2023-08-22
  2. Date Revised 2023-08-22
Further Info :

Pubmed ID

37424270

DOI: Digital Object Identifier

10.2217/pmt-2023-0040

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Languages

English

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