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Investigating the Effectiveness and Tolerability of Intranasal Esketamine Among Older Adults With Treatment-Resistant Depression (TRD): A Post-hoc Analysis from the REAL-ESK Study Group.

Author: AndriolaIleana, CarulloRosalba, ChiappiniStefania, ClericiMassimo, Di LorenzoGiorgio, MartiadisVassilis, MartinottiGiovanni, McIntyreRoger S, PettorrusoMauro, SaniGabriele, SensiStefano L, StefanelliGiulia, VitaAntonio, ZanardiRaffaella, d'AndreaGiacomo

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review discusses the use of esketamine nasal spray (ESK-NS) for treatment-resistant depression (TRD) in older adults. While ESK-NS has demonstrated efficacy and tolerability in clinical trials, real-world data on its effectiveness and safety in this population is limited.
Paper Details　
Original Abstract of the Article :
Treatment-resistant depression (TRD) is a serious and debilitating psychiatric disorder that frequently affects older patients. Esketamine nasal spray (ESK-NS) has recently been approved as a treatment for TRD, with multiple studies establishing its efficacy and tolerability. However, the real-world...See full text at original site
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引用元：
https://doi.org/10.1016/j.jagp.2023.06.016

データ提供：米国国立医学図書館（NLM）

Exploring New Horizons in Treatment-Resistant Depression: Intranasal Esketamine for Older Adults

The quest for effective treatments for [treatment-resistant depression (TRD)] is a long and challenging one, much like a camel traversing a vast desert. This study, like an experienced guide leading a caravan to a hidden oasis, investigates the potential benefits of [intranasal esketamine] for older adults with TRD. The research delves into the real-world effectiveness, tolerability, and safety of this treatment in an age group that often faces unique challenges in managing depression.

A New Oasis of Hope: Intranasal Esketamine for TRD in Older Adults

This study, like a beacon of hope in the desert, explores the potential benefits of [intranasal esketamine] for older adults struggling with [treatment-resistant depression]. The research suggests that this treatment might offer a new path towards improved well-being for this vulnerable population.

Navigating the Terrain: Considerations for Safe and Effective Treatment

While this research offers promising initial insights, like a traveler discovering a new trail in a desert, we must approach this with a cautious optimism, much like a camel navigating a shifting landscape. It is crucial to conduct further research to fully understand the long-term effectiveness, tolerability, and safety of this treatment in older adults. This includes considering potential interactions with other medications and identifying any potential risks specific to this population.

Dr.Camel's Conclusion

The research on intranasal esketamine for TRD in older adults is a valuable step forward, like a camel discovering a new watering hole in a barren desert. While this study offers promising initial findings, we must proceed with caution, much like a wise traveler navigating a challenging terrain. Further research is essential to fully understand the potential benefits, risks, and long-term implications of this treatment for older adults.

Date :
  1. Date Completed 2023-11-10
  2. Date Revised 2023-11-17
Further Info :

Pubmed ID

37479669

DOI: Digital Object Identifier

10.1016/j.jagp.2023.06.016

Related Literature

Article Analysis
・Effects of esketamine nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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