Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases.

Author: DendaMasaya, GodaMitsuhiro, HamanoHirofumi, HigashionnaTsukasa, IshizawaKeisuke, LinTsung-Jen, MiyataKoji, NawaHideki, NeishiMami, NiimuraTakahiro, YagiKenta, ZamamiYoshito

Paper Details 
Original Abstract of the Article :
It is unclear whether the s (-) form of esomeprazole (EPZ) has an improved safety profile when compared with its racemic form omeprazole (OPZ). We assessed the potential complications of these optical isomers when combined with cilostazol, clopidogrel, and prasugrel, which are frequently used concom...See full text at original site
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引用元:
https://doi.org/10.1016/j.taap.2023.116632

データ提供:米国国立医学図書館(NLM)

Unveiling the Secrets of Esomeprazole and Omeprazole: A Deep Dive into Optical Isomers

The world of pharmaceuticals is as complex and intriguing as the shifting sands of a desert. This research, like an exploration into the hidden properties of these compounds, investigates the potential safety profiles of esomeprazole and omeprazole, two optical isomers commonly used to treat heartburn and acid reflux. The authors delve into the vast databases of the JADER and FAERS, searching for clues to the potential complications associated with these medications, particularly when used in combination with other frequently prescribed drugs.

A New Perspective: Exploring the Fine Points of Optical Isomers

This research, like a desert explorer uncovering a hidden oasis, sheds light on the potential differences in safety profiles between esomeprazole and omeprazole. The authors explore the possibility that esomeprazole, the S(-) enantiomer, may possess improved safety characteristics compared to its racemic counterpart, omeprazole. This research opens up new avenues for understanding the subtle nuances of optical isomers and their impact on patient health.

Navigating the Desert of Drug Interactions: Staying Informed

The authors highlight the importance of understanding potential drug interactions, particularly when combining esomeprazole or omeprazole with medications like cilostazol, clopidogrel, and prasugrel. This research, like a guide through a treacherous desert landscape, emphasizes the importance of staying informed about potential risks and benefits associated with medication combinations. Consult with your healthcare provider to discuss any concerns you may have regarding drug interactions.

Dr.Camel's Conclusion

This research, a valuable contribution to the field of pharmaceutical research, provides a deeper understanding of the potential safety profiles of esomeprazole and omeprazole. The authors' exploration into the vast databases of JADER and FAERS, like a careful analysis of desert tracks, sheds light on the complexities of drug interactions and underscores the importance of personalized medication management.

Date :
  1. Date Completed 2023-08-28
  2. Date Revised 2023-09-08
Further Info :

Pubmed ID

37482254

DOI: Digital Object Identifier

10.1016/j.taap.2023.116632

SNS
PICO Info
in preparation
Languages

English

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