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Hypnotic treatment reverses NREM sleep disruption and EEG desynchronization in a mouse model of Fragile X syndrome to rescue memory consolidation deficits.
Author: AtonSara J, BrancaleoneWilliam P, ClawsonBrittany C, DonnellyMarcus J, GarzonValentina Caicedo, JiangSha, MartinezJessy D, Mendez OrtegaStephany L, Perez TrembleRoxanne E, PetersonKathryn G, PopkeDonald S, ShaverJames J, TorresDaniel, WilsonLydia G, YangZhongying
Original Abstract of the Article :
Fragile X syndrome (FXS) is a highly-prevalent genetic cause of intellectual disability, associated with disrupted cognition and sleep abnormalities. Sleep loss itself negatively impacts cognitive function, yet the contribution of sleep loss to impaired cognition in FXS is vastly understudied. One u...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10370139/
データ提供:米国国立医学図書館(NLM)
Restoring Sleep in Fragile X Syndrome: A Desert Oasis for Memory Consolidation
Fragile X syndrome (FXS), a genetic condition associated with intellectual disability, is like a challenging desert environment, impacting cognitive function and sleep. This study, like a research team seeking to restore balance in this disrupted landscape, investigates the potential of hypnotic therapy to improve sleep and cognitive function in FXS.
Hypnotic Therapy: A Desert Oasis for Sleep and Memory
The researchers, like skilled desert engineers, discovered that administration of ML297, a hypnotic drug, reversed sleep disruptions and EEG desynchronization in mice with FXS. Moreover, hypnotic therapy improved memory consolidation in these mice, demonstrating the potential of sleep restoration to enhance cognitive function in FXS. Their findings, like a hidden spring in the desert, offer a glimmer of hope for individuals with this challenging condition.
Restoring Balance in the Desert of FXS
This study provides exciting insights into the potential of hypnotic therapy to improve sleep and cognitive function in FXS, highlighting the close relationship between sleep and cognition. It's like a reminder that even in the desert of FXS, we can find ways to restore balance and improve quality of life.
Dr.Camel's Conclusion
This research highlights the importance of understanding the interplay between sleep and cognitive function, particularly in complex conditions like FXS. It's like a reminder that even in the most challenging desert environments, there are opportunities for restoration and improvement. The study's findings offer a potential new avenue for treating FXS, restoring balance and improving cognitive function for individuals with this condition.
Date :
- Date Completed n.d.
- Date Revised 2023-07-28
Further Info :
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