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1,8-Cineole Alleviates OGD/R-Induced Oxidative Damage and Restores Mitochondrial Function by Promoting the Nrf2 Pathway.

Author: GaoPing, GaoWeijuan, JinXiaofei, LiuZhenyi, MaXian, WangJing, XinZiyuan, YinMeijuan, ZhaoYanmeng, ZhaoYuemou, ZhouXiaohong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

1,8-cineole was found to reduce oxidative stress injury and restore mitochondrial function in OGD/R HT22 cells by activating the Nrf2 signaling pathway. This effect was mediated by the increased expression of NQO1 and HO-1, suggesting potential therapeutic applications for neuroprotection.
Paper Details　
Original Abstract of the Article :
This study examined the effects of 1,8-cineole on reducing oxidative stress injury and restoring mitochondrial function in oxygen-glucose deprivation and reoxygenation (OGD/R) HT22 cells via the nuclear factor erythrocyte 2 related factor 2 (Nrf2) pathway. The optimal concentration of 1,8-cineole to...See full text at original site
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引用元：
https://doi.org/10.1248/bpb.b23-00154

データ提供：米国国立医学図書館（NLM）

1,8-Cineole: A Restorative Oasis for Oxidative Stress

The field of cellular biology is constantly seeking to understand the mechanisms of cellular damage and repair. This research investigates the protective effects of 1,8-cineole, a natural compound found in eucalyptus oil, on cells exposed to oxidative stress. Imagine a desert oasis, 1,8-cineole acts as a source of resilience and rejuvenation for stressed cells.

1,8-Cineole's Protective Effects

This study demonstrates that 1,8-cineole can effectively reduce oxidative damage and restore mitochondrial function in cells exposed to oxygen-glucose deprivation and reoxygenation (OGD/R). This protective effect is mediated by the activation of the Nrf2 pathway, a key signaling pathway involved in cellular defense against oxidative stress. It's like a caravan equipped with a protective shield, 1,8-cineole helps cells navigate the harsh desert of oxidative stress.

Implications for Cellular Health

These findings suggest that 1,8-cineole could have therapeutic potential for conditions associated with oxidative stress, such as neurodegenerative diseases and aging. It's a promising development in the quest for natural compounds that can enhance cellular resilience and promote overall health.

Dr.Camel's Conclusion

This research highlights the potential of 1,8-cineole as a natural protector against oxidative stress. Its ability to activate the Nrf2 pathway offers a promising strategy for promoting cellular health and combating the damaging effects of oxidative stress.

Date :
  1. Date Completed 2023-10-03
  2. Date Revised 2023-10-03
Further Info :

Pubmed ID

37532524

DOI: Digital Object Identifier

10.1248/bpb.b23-00154

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