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Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis.

Author: BurschinskiAngelika, DavisJohn M, LeuchtStefan, NomuraNobuyuki, Schneider-ThomaJohannes, SiafisSpyridon, TakeuchiHiroyoshi, WangDongfang, WuHui

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and dose-response meta-analysis investigated the relationship between dose and extrapyramidal side-effects (EPS) associated with antipsychotic drugs. The study found that most antipsychotics were associated with dose-dependent EPS, with the risk increasing substantially when dopamine D2 receptor (D2R) occupancy exceeded 75-85%.
Paper Details　
Original Abstract of the Article :
Antipsychotic drugs differ in their propensity to cause extrapyramidal side-effects (EPS), but their dose-effects are unclear. Therefore, we conducted a systematic review and dose-response meta-analysis. We searched multiple electronic databases up to 20.02.2023 for fixed-dose studies investigating ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10618092/

データ提供：米国国立医学図書館（NLM）

Antipsychotic Dose, Dopamine D2 Receptor Occupancy and Extrapyramidal Side-Effects: A Systematic Review and Dose-Response Meta-Analysis

Antipsychotic medications are often used to treat conditions like schizophrenia, but they can come with side effects, such as extrapyramidal side effects (EPS). This study aimed to understand the relationship between antipsychotic dose, dopamine D2 receptor (D2R) occupancy, and the risk of EPS. The researchers conducted a systematic review and dose-response meta-analysis of data from 110 studies involving 38,200 participants. They found that most antipsychotics were associated with a dose-dependent increase in EPS, with varying degrees of risk. The study also found that the risk of EPS increased substantially when D2R occupancy exceeded 75-85%, except for D2R partial agonists.

Navigating the Desert of Antipsychotic Treatment

This study provides valuable insights for doctors and patients navigating the complexities of antipsychotic treatment. The research highlights the importance of understanding the dose-response relationship between antipsychotics and EPS, helping clinicians to tailor treatment plans to minimize the risk of side effects.

The Desert of Side Effects

This study offers a comprehensive overview of the relationship between antipsychotic dose, D2R occupancy, and EPS. The researchers have carefully analyzed the data from numerous studies, providing a detailed map of the desert of antipsychotic side effects. The findings are essential for doctors and patients to make informed decisions about treatment, balancing the benefits of antipsychotics with the potential risks of EPS.

Dr.Camel's Conclusion

This study sheds light on the complex landscape of antipsychotic treatment. The researchers have mapped the relationship between dose, receptor occupancy, and EPS, providing valuable information for clinicians and patients. By understanding these relationships, we can better navigate the desert of antipsychotic treatment, making informed decisions that prioritize patient safety and well-being.

Date :
  1. Date Completed 2023-11-02
  2. Date Revised 2023-11-03
Further Info :

Pubmed ID

37537284

DOI: Digital Object Identifier

PMC10618092

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Languages

English

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