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Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic.

Author: CiechomskaMarzena, Kuca-WarnawinEwa, WrońskiJakub

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review summarizes the impact of methotrexate on the immunogenicity of vaccines in adult rheumatology patients. It covers studies on the effect of methotrexate on various vaccines, including influenza, pneumococcal, herpes zoster, tetanus/diphtheria/pertussis, hepatitis A, yellow fever, and COVID-19 vaccines, and provides evidence for recommendations regarding methotrexate use during and after vaccination.
Paper Details　
Original Abstract of the Article :
Despite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack...See full text at original site
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引用元：
https://doi.org/10.1016/j.biopha.2023.115254

データ提供：米国国立医学図書館（NLM）

Methotrexate and Vaccine Immunogenicity: Lessons Learned from the COVID-19 Pandemic

Methotrexate is a commonly used immunomodulatory drug in rheumatology, but its impact on vaccine immunogenicity has been a topic of ongoing debate. This review examines the effect of methotrexate on vaccine responses in adult rheumatological patients, drawing on lessons learned from the COVID-19 pandemic.

Navigating the Impact of Methotrexate on Vaccine Responses

The authors provide a comprehensive overview of studies on the effect of methotrexate on the immunogenicity of various vaccines, including influenza, pneumococcal, herpes zoster, and COVID-19. They discuss the potential mechanisms by which methotrexate might modulate immune responses and present evidence for recommendations regarding methotrexate use during vaccination.

Understanding the Complexities of Immunomodulation

This review highlights the intricate interplay between methotrexate, the immune system, and vaccine responses. The findings underscore the importance of considering the potential impact of immunomodulatory therapies on vaccine efficacy and making informed decisions regarding medication management during vaccination. It’s like navigating a delicate ecosystem – carefully considering the effects of each intervention to ensure a balanced and healthy environment.

Dr.Camel's Conclusion

This review provides valuable insights into the complex relationship between methotrexate and vaccine immunogenicity. It emphasizes the need for individualized approaches to medication management and vaccination strategies to optimize outcomes for patients with autoimmune inflammatory rheumatic diseases.

Date :
  1. Date Completed 2023-08-17
  2. Date Revised 2023-08-17
Further Info :

Pubmed ID

37542854

DOI: Digital Object Identifier

10.1016/j.biopha.2023.115254

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・Effective treatment of vaccines
SNS
PICO Info
in preparation
Languages

English

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