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A novel subclonal rearrangement of the STRN3::PDGFRB gene in de novo acute myeloid leukemia with NPM1 mutation and its leukemogenic effects.

Author: GaoXin, GuRunxia, LiuTing, LiuWenbing, MiYingchang, QiuShaowei, SongYang, TianZheng, WanLi, WangJianxiang, WangMin, WangZhe, WeiShuning

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study identified a novel fusion gene, STRN3::PDGFRB, in a patient with acute myeloid leukemia (AML). The fusion protein exhibited leukemogenic effects and sensitivity to tyrosine kinase inhibitors (TKIs) and selinexor, suggesting potential therapeutic options for patients with this mutation.
Paper Details　
Original Abstract of the Article :
Chromosome translocations in the 5q31-33 region are associated with a range of hematologic malignancies, some of which involve the platelet-derived growth factor receptor beta (PDGFRB) gene. We report a case of acute myeloid leukemia (AML) with a mutation in the NPM1 gene (NPM1-mut AML) and a subclo...See full text at original site
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引用元：
https://doi.org/10.1038/s41417-023-00651-w

データ提供：米国国立医学図書館（NLM）

A Novel Subclonal Rearrangement in AML: Unveiling the Leukemogenic Effects of STRN3::PDGFRB

The world of cancer genomics, like a desert with hidden treasures, is constantly revealing new insights. This study uncovers a novel subclonal rearrangement of the STRN3::PDGFRB gene in acute myeloid leukemia (AML), offering a deeper understanding of the complexities of this disease.

The authors, like meticulous desert explorers, identify a new fusion gene, STRN3::PDGFRB, formed by a t(5;14) chromosomal rearrangement. This discovery sheds light on the intricate mechanisms of AML development and provides valuable insights into potential therapeutic targets.

STRN3::PDGFRB: A Novel Fusion Gene in AML

This study, like a landmark discovery in the desert of AML research, unveils a previously unknown fusion gene, STRN3::PDGFRB, contributing to the development of AML. The identification of this novel gene provides crucial insights into the complexities of AML and offers a potential target for future therapeutic strategies.

Understanding Clone Evolution in AML: A Complex Journey

This research delves into the fascinating world of clone evolution in AML, highlighting the dynamic nature of this disease. The study emphasizes the importance of understanding the intricacies of clone development and the potential impact of subclonal rearrangements on therapeutic responses.

Dr. Camel's Conclusion

The desert of AML research is vast and intricate, but this study reveals a hidden treasure: the novel fusion gene STRN3::PDGFRB. This discovery adds a new dimension to our understanding of AML and offers a potential target for future therapies. It's a reminder that the journey to conquer AML is ongoing, and continuous research is essential to unlock new insights and develop more effective treatment strategies.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-11-14
Further Info :

Pubmed ID

37550570

DOI: Digital Object Identifier

10.1038/s41417-023-00651-w

Related Literature

Article Analysis
・Side Effects of selinexor
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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