Paper Details

  1. Home
  2. Paper Details

Clinical efficacy and safety of Zuranolone (SAGE-217) in individuals with major depressive disorder.

Author: BaileyJulia B, CaoBing, CebanFelicia, Di VincenzoJoshua D, HoRoger C, KwanAngela T H, McIntyreRoger S, MeshkatShakila, RheeTaeho Greg, RosenblatJoshua D, TeopizKayla M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Zuranolone is a novel oral neuroactive steroid that has shown promising results in treating major depressive disorder (MDD). In seven studies involving 1662 participants, Zuranolone demonstrated rapid and clinically significant antidepressant effects, with an acceptable safety profile and a low rate of serious adverse events. It is believed that Zuranolone's efficacy stems from its ability to enhance inhibitory GABAergic signaling.
Paper Details　
Original Abstract of the Article :
Major depressive disorder (MDD) is a common mental disorder with a high rate of morbidity and mortality. Dysfunctional signaling of gamma-aminobutyric acid (GABA) has been implicated in some studies in the etiology of MDD. Zuranolone (SAGE-217) is a novel, oral neuroactive steroid and an investigati...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.jad.2023.08.027

データ提供：米国国立医学図書館（NLM）

Zuranolone: A New Hope in the Desert of Depression?

The desert of [major depressive disorder (MDD)] is a desolate and unforgiving place, where hope can seem as elusive as a mirage. This research delves into the potential of [Zuranolone (SAGE-217)] as a novel treatment option for this debilitating condition. The study explores the mechanism of action of Zuranolone, examining its impact on [gamma-aminobutyric acid (GABA)] signaling and its potential to bring relief to those struggling with MDD.

A Promising New Direction in Depression Treatment

Imagine the brain as a vast desert, where neurons communicate through intricate pathways. Zuranolone, like a refreshing oasis, appears to enhance communication between neurons, potentially alleviating the symptoms of depression. The study found that Zuranolone was associated with [rapid, clinically meaningful antidepressant effects] and an acceptable level of [treatment-emergent adverse events]. The study provides a beacon of hope, suggesting that Zuranolone could be a valuable tool in the fight against MDD.

Navigating the Desert of Depression with Zuranolone

The research suggests that Zuranolone could be a promising new approach to managing MDD. Just as a well-placed oasis can provide much-needed relief to a weary traveler, Zuranolone holds the potential to bring hope and healing to those who have lost their way in the desert of depression. However, further research is needed to explore the long-term effects of this treatment and its potential applications in other diagnostic entities.

Dr.Camel's Conclusion

This study provides a promising glimpse into the future of depression treatment, suggesting that Zuranolone could be a valuable addition to the therapeutic landscape. Like a refreshing oasis in the desert of despair, Zuranolone offers hope for a brighter future for those struggling with MDD.

Date :
  1. Date Completed 2023-09-11
  2. Date Revised 2023-09-12
Further Info :

Pubmed ID

37557991

DOI: Digital Object Identifier

10.1016/j.jad.2023.08.027

Related Literature

Article Analysis
・Effects of zuranolone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.