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In-depth mass spectrometry analysis of rhGH administration altered energy metabolism and steroidogenesis.

Author: QiaoLiang, WangYang, XuXin, ZhaoDan, ZhuangWenqian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of a single injection of recombinant human growth hormone (rhGH) on healthy young men using metabolomics. It revealed changes in energy-related pathways (amino acid, nucleotide metabolism, glycolysis, and TCA cycle) and urinary steroid profiles, suggesting a role of rhGH in energy metabolism and steroidogenesis.
Paper Details　
Original Abstract of the Article :
Growth hormone, as a proteohormone, is primarily known of its dramatic effect on longitudinal growth. Recombinant DNA technology has provided a safe, abundant and comparatively cheap supply of human GH for growth hormone-deficient individuals. However, many healthy subjects, especially athletics, ad...See full text at original site
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引用元：
https://doi.org/10.1016/j.talanta.2023.125069

データ提供：米国国立医学図書館（NLM）

Exploring the Desert of rhGH Effects: Uncovering the Hidden Oasis

Growth hormone (GH) is a key player in the desert of human growth and development. This study investigates the effects of recombinant human GH (rhGH) administration on energy metabolism and steroidogenesis in healthy individuals. The researchers used mass spectrometry to analyze the metabolic changes induced by rhGH. Their findings reveal that rhGH alters various metabolic pathways, including amino acid metabolism, nucleotide metabolism, glycolysis, and the tricarboxylic acid (TCA) cycle. Furthermore, the study sheds light on the potential role of rhGH in steroidogenesis.

Unraveling the Secrets of rhGH: A New Oasis of Understanding

This study adds a new dimension to our understanding of rhGH's impact on the human body. The findings reveal that rhGH administration has far-reaching effects on energy metabolism and steroidogenesis, highlighting the complex interplay of this hormone in various physiological processes.

Navigating the Desert of Hormonal Influences

This research underscores the importance of understanding the subtle effects of hormones on our bodies. It provides a valuable glimpse into the intricate world of metabolic pathways and their regulation by hormones like rhGH. This knowledge can inform future research and clinical applications of rhGH.

Dr. Camel's Conclusion

This study, like a wandering explorer venturing into the vast desert of human physiology, unveils the multifaceted effects of rhGH. It provides a deeper understanding of how this hormone influences energy metabolism and steroidogenesis. As we continue to explore the desert of hormonal influences, we gain a more comprehensive view of human health and well-being.

Date :
  1. Date Completed 2023-09-15
  2. Date Revised 2023-09-15
Further Info :

Pubmed ID

37574608

DOI: Digital Object Identifier

10.1016/j.talanta.2023.125069

Related Literature

Article Analysis
・Health effects of athletics
SNS
PICO Info
in preparation
Languages

English

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