Paper Details 
Original Abstract of the Article :
Despite its efficacy for treating androgenetic alopecia, finasteride, an inhibitor of 5α-reductase (i.e., the enzyme converting testosterone, T, into dihydrotestosterone, DHT), is associated with several side effects including sexual dysfunction (e.g., erectile dysfunction). These side effects ...See full text at original site
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引用元:
https://doi.org/10.1111/andr.13515

データ提供:米国国立医学図書館(NLM)

Finasteride and Erectile Dysfunction: Exploring the Desert of Sexual Health

The vast desert of sexual health is a complex and often misunderstood landscape. This research examines the effects of finasteride, a drug commonly used to treat androgenetic alopecia, on erectile function in rats. Using a controlled experiment, the researchers investigated the impact of finasteride treatment and withdrawal on the corpus cavernosum, the erectile tissue in the penis. They discovered that finasteride treatment decreased levels of the enzyme 5α-reductase type II, which is involved in the conversion of testosterone to dihydrotestosterone. This led to a decrease in nitric oxide synthase (NOS) activity and alterations in the levels of other molecules involved in erectile function. Interestingly, these changes were reversed after the drug was withdrawn.

Finasteride: Potential Effects on Erectile Function

This research suggests that finasteride may have a negative impact on erectile function, even after the drug is discontinued. The study's findings raise concerns about the potential for long-term sexual side effects associated with finasteride use. Further research is needed to fully understand the mechanisms involved and to develop strategies for mitigating these potential side effects. This research highlights the importance of considering the broader implications of drug use, beyond the intended therapeutic benefits.

Finasteride and Post-Finasteride Syndrome (PFS)

The researchers' findings raise concerns about the potential role of finasteride in the development of post-finasteride syndrome (PFS), a controversial condition characterized by persistent sexual dysfunction. While further research is needed to clarify the relationship between finasteride and PFS, this research underscores the importance of being aware of the potential long-term consequences of drug use. It's crucial for patients and healthcare providers to engage in open discussions about the risks and benefits of treatment, including potential long-term side effects.

Dr.Camel's Conclusion

Navigating the desert of sexual health requires careful consideration of the potential impact of medications. This research provides valuable insights into the potential effects of finasteride on erectile function, raising concerns about its long-term consequences. It's important to be aware of these potential risks and to engage in open discussions with healthcare providers about the best treatment options. The desert of sexual health is vast and complex, requiring careful navigation to ensure well-being and satisfaction.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-25
Further Info :

Pubmed ID

37621185

DOI: Digital Object Identifier

10.1111/andr.13515

Related Literature

SNS
PICO Info
in preparation
Languages

English

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