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Effects of Doxycycline Treatment on Hematological Parameters, Viscosity, and Cytokines in Canine Monocytic Ehrlichiosis.

Author: AlmeidaArleana do Bom Parto Ferreira de, CardosoSaulo Pereira, CotrimAron Carlos de Melo, Fagundes-TrichesDanny Laura Gomes, FrançaDanielle Cristina Honorio, FrançaEduardo Luzía, Honorio-FrançaAdenilda Cristina, NevesMaria Clara Bianchini, SilvaLuana Paula Sales, SousaValéria Régia Franco

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

यो अध्ययनले डक्सिसाइक्लिनको उपचार बिना र डक्सिसाइक्लिनको उपचार भएका इरिलिचिया क्यानिस द्वारा संक्रमित कुकुरहरूमा हेमेटोलोजिकल प्यारामिटरहरू, रगतको चिपचिपापन र साइटोकिनहरूको विश्लेषण गर्ने लक्ष्य राखेको छ। 36 कुकुरहरूलाई इरिलिचिया क्यानिस संकलन भएको शंका गरिएको थियो जुन परमाणु पोलिमरेज चेन रिएक्शन परीक्षणहरूद्वारा पुष्टि भएको थियो। अध्ययनमा, 7 कुकुरहरू इरिलिचिया क्यानिस संकलन बिना, 7 कुकुरहरू इरिलिचिया क्यानिस संकलन भएका तर उपचार नगरेका र 11 कुकुरहरू स्वस्थ थिए। डक्सिसाइक्लिनको उपचारले इरिलिचिया क्यानिस संकलन भएका कुकुरहरूमा कुल ल्युकोसाइटहरू र ल्युकोसाइटहरूको संख्या कम भएको पाइयो। उपचार नगरेका इरिलिचिया क्यानिस संकलन भएका कुकुरहरूमा इओसिनोफिलहरू र प्लेटलेटहरू कम भएको पाइयो। डक्सिसाइक्लिनको उपचारले इरिलिचिया क्यानिस संकलन भएका कुकुरहरूमा मोनासाइटहरू, इओसिनोफिलहरू र प्लेटलेटहरू बढेको पाइयो। इरिलिचिया क्यानिस संकलन भएका कुकुरहरूमा स्वस्थ कुकुरहरूको तुलनामा रगतको चिपचिपापन कम देखियो। इरिलिचिया क्यानिस संकलन भएका कुकुरहरूमा TNF-α कम र IL-1β बढी देखियो।
Paper Details　
Original Abstract of the Article :
This study aimed to analyze the hematological parameters, blood viscosity, and cytokines of dogs infected by <i>Ehrlichia canis</i> untreated and treated with doxycycline. Initially, 47 dogs were examined, and 36 were suspected to have canine monocytic ehrlichiosis, which was confirmed through molec...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10452297/

データ提供：米国国立医学図書館（NLM）

Doxycycline Treatment for Canine Monocytic Ehrlichiosis: A Balancing Act

Canine monocytic ehrlichiosis, a tick-borne disease, can be a serious health concern for our furry friends. This study explores the effects of doxycycline, a common antibiotic, on hematological parameters, blood viscosity, and cytokine levels in dogs infected with *Ehrlichia canis*. The researchers studied 25 dogs, including 11 healthy dogs and 14 dogs infected with *E. canis*, comparing the effects of doxycycline treatment to no treatment. The study found that while doxycycline treatment successfully increased platelet and eosinophil levels, it also led to an increase in monocyte levels and elevated levels of the inflammatory cytokine IL-1β, potentially exacerbating inflammation. Furthermore, regardless of treatment, infected dogs had lower blood viscosity, lower TNF-α levels, and higher IL-1β levels compared to healthy dogs.

Doxycycline: A Double-Edged Sword for Canine Ehrlichiosis

The study highlights the complex interplay between doxycycline treatment and the immune response in dogs with ehrlichiosis. It's like navigating a delicate desert ecosystem - while doxycycline can help to control the infection, it can also have unintended consequences on the immune system, requiring careful monitoring.

Managing Canine Ehrlichiosis: A Journey Through the Desert of Health

Canine monocytic ehrlichiosis can be a serious health threat to dogs. If you notice any signs of illness in your dog, consult a veterinarian immediately for proper diagnosis and treatment. Preventing tick exposure through preventative measures and prompt tick removal can play a significant role in protecting your furry friend.

Dr.Camel's Conclusion

Doxycycline treatment for canine monocytic ehrlichiosis can have both beneficial and potentially detrimental effects. While it can improve some hematological parameters, it can also exacerbate inflammation. Careful monitoring of blood parameters and cytokine levels is essential when treating ehrlichiosis. Remember, treating canine ehrlichiosis is like navigating a desert oasis - finding the right balance between treatment and the potential side effects is crucial for ensuring the health and well-being of your furry friend.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-08-28
Further Info :

Pubmed ID

37627021

DOI: Digital Object Identifier

PMC10452297

Related Literature

Article Analysis
・Effects of doxycycline
SNS
PICO Info
in preparation
Languages

English

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