Segmental analysis and long-term monitoring of vadadustat in equine hair for the purpose of doping control.

Author: IshiiHideaki, ItoHideki, KamiyaTakahiro, KusanoKanichi, LeungGary Ngai-Wa, MiyataKenji, ShibuyaMariko, SoneYu, WakunoAi, YamadaMasayuki

Paper Details 
Original Abstract of the Article :
Vadadustat is a newly launched hypoxia-inducible factor stabilizer with anti-anemia and erythropoietic effects; however, its use in horses is expressly forbidden in both racing and equestrian competitions. Following our previous report on the pharmacokinetic study of vadadustat in horse plasma and u...See full text at original site
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引用元:
https://doi.org/10.1093/jat/bkad057

データ提供:米国国立医学図書館(NLM)

Vadadustat in Equine Hair: Tracking a Doping Agent Through Time

The world of sports doping is a complex and often hidden one, like a secret oasis in the desert. Vadadustat, a newly launched hypoxia-inducible factor stabilizer with anti-anemia effects, is prohibited in equestrian competitions. This study, like a research expedition into this hidden world, investigates the long-term presence of vadadustat in equine hair, seeking to extend the detection window for doping control.

Researchers, like skilled trackers in the desert, analyzed hair samples collected from horses after vadadustat administration. They found that vadadustat was detectable in hair samples for up to 6 months, like a trail left by a caravan in the sand. Their findings, like a map leading to a hidden treasure, provide valuable insights into the persistence of vadadustat in hair, extending the detection window for doping control.

The researchers also observed that the concentration of vadadustat in hair segments varied over time, like a shifting sand dune in the desert, suggesting that segmental analysis could be a valuable tool for reconstructing the timeline of vadadustat use.

A New Frontier in Doping Detection: The Hair Trail

The study findings, like a well-placed oasis, offer a significant advancement in doping detection strategies. This approach, like a new weapon against cheating in sports, can provide a more comprehensive and long-term assessment of vadadustat use, helping to ensure fair play in equestrian competitions.

Navigating the Desert of Doping Control: A Long-Term Perspective

This study, like a beacon in the desert, emphasizes the importance of a long-term perspective in doping control. It underscores the need for innovative strategies and ongoing research to stay ahead of doping practices and ensure a level playing field for all athletes.

Dr.Camel's Conclusion

This study, like a caravan crossing a vast desert, brings us closer to understanding the complex terrain of doping control. The researchers, like skilled trackers, have uncovered valuable insights into the long-term persistence of vadadustat in equine hair, offering a new weapon in the fight against doping. As we continue our journey through the desert of sports integrity, this study serves as a reminder of the importance of innovation, perseverance, and collaboration in our quest for fair play and a level playing field for all athletes.

Date :
  1. Date Completed 2023-09-18
  2. Date Revised 2023-09-18
Further Info :

Pubmed ID

37632695

DOI: Digital Object Identifier

10.1093/jat/bkad057

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Languages

English

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