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Developmental reprogramming of myometrial stem cells by endocrine disruptor linking to risk of uterine fibroids.
Author: Al-HendyAyman, AliMohamed, MasAymara, TreviñoLindsey S, YangQiwei
Original Abstract of the Article :
BACKGROUND: The stage, when tissues and organs are growing, is very vulnerable to environmental influences, but it's not clear how exposure during this time causes changes to the epigenome and increases the risk of hormone-related illnesses like uterine fibroids (UFs). METHODS: Developmental reprog...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471700/
データ提供:米国国立医学図書館(NLM)
Endocrine Disruptors and Uterine Fibroids: A Tale of Developmental Reprogramming
The field of [endocrine disruptors] is a fascinating one, exploring the complex interplay between environmental factors and human health. This study investigates the potential role of [endocrine disruptors] in the development of [uterine fibroids], focusing on the [developmental reprogramming of myometrial stem cells]. The researchers used [RNA-seq, ChIP-seq, RRBS, gain/loss of function analysis, and luciferase activity assays] to examine the effects of [diethylstilbestrol] on [myometrial stem cells] in both [in vitro and in vivo] models. Their findings provide compelling evidence for the role of [endocrine disruptors] in [epigenetically reprogramming myometrial stem cells], potentially increasing the risk of [uterine fibroids].
A Window into the Epigenome: Endocrine Disruptors and Uterine Fibroids
This study reveals a crucial link between [endocrine disruptors] and [uterine fibroids]. The researchers discovered that [diethylstilbestrol] can [epigenetically reprogram myometrial stem cells], leading to increased [estrogen activity] and potentially increasing the risk of [uterine fibroids]. These findings underscore the importance of understanding the long-term effects of [endocrine disruptors] on human health, particularly during development.
Protecting Our Future: A Call for Environmental Awareness
This research serves as a powerful reminder of the interconnectedness between our environment and our health. The findings highlight the potential hazards of [endocrine disruptors] and their ability to impact our bodies, even at the cellular level. This study emphasizes the need for proactive measures to minimize exposure to [endocrine disruptors] and protect our health, particularly during the vulnerable stages of development.
Dr. Camel's Conclusion
Imagine a desert landscape, where a single drop of water can create a vibrant oasis. Similarly, a seemingly small environmental factor, like an [endocrine disruptor], can have a profound impact on our health. This study reveals the intricate interplay between [endocrine disruptors], [epigenetics], and the development of [uterine fibroids]. It's a powerful reminder of the need to protect ourselves and future generations from the potential dangers of [endocrine disruptors].
Date :
- Date Completed 2023-09-01
- Date Revised 2023-09-22
Further Info :
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