Paper Details 
Original Abstract of the Article :
Intravenous epoprostenol improves exercise capacity and survival in patients with pulmonary arterial hypertension (PAH); however, it has side effects. Reviewing the side effects associated with epoprostenol and treprostinil is essential for improving the long-term treatment strategies for PAH. This ...See full text at original site
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引用元:
https://doi.org/10.1016/j.amjcard.2023.08.078

データ提供:米国国立医学図書館(NLM)

Transitioning from Epoprostenol to Treprostinil: A Smoother Path Through Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is a serious and life-threatening condition characterized by high blood pressure in the arteries of the lungs. This study investigates the transition from intravenous epoprostenol, a common treatment for PAH, to intravenous treprostinil due to intolerable side effects. The researchers identified a significant number of patients who experienced troublesome side effects from epoprostenol, including high cardiac output symptoms, ascites, and thrombocytopenia. Switching to treprostinil effectively ameliorated these side effects, allowing patients to continue their prostacyclin therapy without significant discomfort. This research highlights the importance of considering alternative treatment options for patients experiencing intolerable side effects from their current medications.

Finding the Right Path in Pulmonary Arterial Hypertension: A Personalized Approach

The study demonstrates the need for personalized treatment approaches in PAH, considering the individual patient's response to medications and potential side effects. Switching from epoprostenol to treprostinil effectively resolved the intolerable side effects experienced by a significant number of patients, allowing them to continue their prostacyclin therapy without significant discomfort. This research emphasizes the importance of individualizing treatment strategies and considering alternative options when necessary to ensure optimal patient outcomes.

From Sandstorms to Serenity: Navigating the Terrain of PAH Treatment

This research underscores the importance of careful medication management and the need for flexibility in treatment approaches. By recognizing and addressing intolerable side effects, clinicians can ensure that patients receive the most effective and tolerable treatment options, maximizing their quality of life and minimizing the impact of their condition. This study serves as a reminder that the journey through PAH treatment can be unpredictable, requiring a collaborative approach between clinicians and patients to navigate the terrain and achieve the best possible outcomes.

Dr. Camel's Conclusion

The study's findings highlight the importance of considering alternative treatment options for patients experiencing intolerable side effects from their medications. Just as a camel may choose a different route through the desert to avoid a sandstorm, clinicians can adapt treatment approaches to ensure the comfort and well-being of their patients. By embracing personalized medicine and considering alternative therapies, we can pave the way for a more comfortable and effective journey through PAH treatment.
Date :
  1. Date Completed n.d.
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

37677880

DOI: Digital Object Identifier

10.1016/j.amjcard.2023.08.078

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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