Sodium-glucose cotransporter-2 inhibitors for hypergycemia in phosphoinositide 3-kinase pathway inhibition.

Author: DeMatteoRaymond, FloryJames H, GoncalvesMarcus DaSilva, LiuDazhi, WeintraubMichael A

Paper Details 
Original Abstract of the Article :
Phosphoinositide 3-kinase (PI3K) inhibition is used for the treatment of certain cancers, but can cause profound hyperglycemia and insulin resistance, for which sodium-glucose cotransporter-2 (SGLT2) inhibitors have been proposed as a preferred therapy. The objective of this research is to assess th...See full text at original site
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引用元:
https://doi.org/10.1007/s10549-023-07110-y

データ提供:米国国立医学図書館(NLM)

SGLT2 Inhibitors: A Refreshing Oasis for Hyperglycemia in PI3K Inhibition

The landscape of cancer treatment is constantly evolving, with new therapies emerging like fertile oases in a vast desert. This study delves into the intriguing intersection of PI3K inhibition and hyperglycemia, exploring the potential of SGLT2 inhibitors as a therapeutic solution. PI3K inhibitors, while valuable in combating certain cancers, can also cause significant hyperglycemia. The researchers, like astute desert explorers, seek to uncover the effectiveness and safety of SGLT2 inhibitors in mitigating this unwelcome side effect.

A Novel Approach: SGLT2 Inhibitors Offer a New Perspective

This research illuminates the potential of SGLT2 inhibitors as a valuable tool for managing hyperglycemia induced by PI3K inhibition. The study findings offer a promising avenue for improving patient outcomes and alleviating the burden of this side effect. This is akin to discovering a hidden oasis in the heart of a desert, offering a much-needed respite from the harsh conditions.

Navigating the Challenges: Safety and Effectiveness

The study explores both the effectiveness and safety of SGLT2 inhibitors in this specific context. The researchers, like meticulous cartographers, meticulously map the potential benefits and risks of this treatment approach. This comprehensive evaluation is crucial for ensuring the long-term well-being of patients undergoing PI3K inhibition therapy.

Dr. Camel's Conclusion

This research represents a significant step forward in understanding the complex interplay of cancer treatment and hyperglycemia. The potential of SGLT2 inhibitors as a therapeutic solution offers a beacon of hope for patients struggling with this side effect. This study provides a valuable guide for navigating this challenging terrain, highlighting the importance of continued research and innovation in the field of oncology.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-21
Further Info :

Pubmed ID

37704834

DOI: Digital Object Identifier

10.1007/s10549-023-07110-y

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English

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