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Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes.

Author: CharrabiAzzouz, ChenShuibing, CheungJim W, ColombaniSarah, EvansTodd, JaffréFabrice, LacampagneAlain, LermanBruce B, MarksAndrew R, MeliAlbano C, PasquiéJean-Luc, ReikenSteven, SittenfeldLeah R, SleimanYvonne

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Polymorphic ventricular tachycardia (PMVT) is a rare genetic heart condition that can cause sudden cardiac death. This study evaluated the effects of different anti-arrhythmic drugs on PMVT-specific heart cells, aiming to develop personalized medicine approaches for this disease.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND">Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac death, typically exercise-induced. We previously showed a link between the RyR2-H29D mutation and a clinical phenotype of...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10517551/

データ提供：米国国立医学図書館（NLM）

Personalized Medicine in a Dish: A Quest for Calcium Leak Prevention

Polymorphic ventricular tachycardia (PMVT) is a rare heart condition that can be as unpredictable as a desert mirage, appearing and disappearing unexpectedly. This study investigates the potential for personalized medicine to prevent calcium leaks, a key factor contributing to PMVT. Researchers employed patient-specific hiPSC-derived cardiomyocytes (hiPSC-CMs) to model the disease in a dish, mimicking the intricate workings of the heart. Their focus was on the RyR2-H29D mutation, linked to a specific PMVT phenotype, and on the effects of various anti-arrhythmic drugs on calcium handling and contractile function. The study highlights the potential for personalized medicine, where treatment strategies are tailored to individual genetic profiles, offering a glimmer of hope for those with PMVT.

A New Oasis in the Desert: Personalized Medicine for PMVT

This study, like a desert oasis, offers a promising new direction in the treatment of PMVT. By using patient-specific hiPSC-CMs, researchers can create a personalized model of the disease, enabling them to test the effectiveness of various drugs in a highly targeted manner. This approach holds great potential for optimizing treatment outcomes and improving the lives of those affected by PMVT.

Health Benefits and Daily Application

While this research is still in its early stages, it underscores the transformative power of personalized medicine. As technology advances, we can expect to see more tailored approaches to treating complex diseases, offering hope for a healthier future.

Dr. Camel's Conclusion

This study offers a glimpse into the future of medicine, where individualized treatment approaches can lead to more effective and personalized care. Like a camel navigating a vast and challenging desert, researchers are tirelessly searching for new solutions to complex diseases, utilizing innovative techniques like hiPSC-CMs to pave the way for a healthier tomorrow.

Date :
  1. Date Completed 2023-09-25
  2. Date Revised 2023-11-21
Further Info :

Pubmed ID

37740238

DOI: Digital Object Identifier

PMC10517551

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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