Paper Details 
Original Abstract of the Article :
Hydroxychloroquine (HCQ) is obtained by hydroxylation of chloroquine (CQ) and the first indication was malaria. Nowadays, HCQ is commonly used in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) with favorable results. Antiphospholipid syndrome (APS) is an autoimmune disease characte...See full text at original site
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引用元:
https://doi.org/10.1007/s00296-023-05457-5

データ提供:米国国立医学図書館(NLM)

The Promise of Hydroxychloroquine in Refractory Obstetric Antiphospholipid Syndrome

This review delves into the use of hydroxychloroquine (HCQ) in the management of refractory obstetric antiphospholipid syndrome (APS). The review explores the mechanism of action of HCQ in APS, highlighting its ability to bind sialic acid, block antiphospholipid antibodies, and modulate pH levels. The review summarizes the known modulating effects of HCQ and CQ, their side effects and use in APS and different pathologies to understand the benefit effects and the mechanism of action of HCQ in refractory obstetric APS. While HCQ has shown promising results in some cases of refractory obstetric APS, further research is needed to fully elucidate its precise mechanisms of action in this specific context.

A Potential New Avenue for Treatment of Refractory Obstetric Antiphospholipid Syndrome

The review suggests that HCQ may offer a promising therapeutic option for women with refractory obstetric APS, a challenging condition that often leads to adverse pregnancy outcomes despite conventional treatments. The review indicates that HCQ, when used in conjunction with standard treatments, has shown potential benefits in some patients. This finding is encouraging and highlights the need for further research to investigate the role of HCQ in managing this complex condition.

Navigating the Potential Benefits and Risks of Hydroxychloroquine

The review acknowledges the potential benefits of HCQ in managing refractory obstetric APS. However, it also emphasizes the importance of careful consideration of its potential side effects. As with any medication, a thorough assessment of individual patient factors and potential risks is crucial before initiating treatment with HCQ. The review's comprehensive analysis of the potential benefits and risks associated with HCQ provides valuable insights for healthcare professionals involved in the management of refractory obstetric APS.

Dr. Camel's Conclusion

Think of a camel caravan crossing a vast desert. The journey is fraught with challenges, much like the path of a woman facing refractory obstetric APS. HCQ might be like a life-giving spring discovered along the way, offering a chance for a smoother passage. While the journey may not be guaranteed, HCQ's potential to alleviate the burdens of this condition is a promising development that warrants further exploration.

Date :
  1. Date Completed n.d.
  2. Date Revised 2023-09-23
Further Info :

Pubmed ID

37741812

DOI: Digital Object Identifier

10.1007/s00296-023-05457-5

Related Literature

SNS
PICO Info
in preparation
Languages

English

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