Paper Details 
Original Abstract of the Article :
Parenteral depot systems can provide a constant release of drugs over a few days to months. Most of the parenteral depot products on the market are based on poly(lactic acid) and poly(lactide-<i>co</i>-glycolide) (PLGA). Studies have shown that acidic monomers of these polymers can lead to nonlinear...See full text at original site
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引用元:
https://doi.org/10.1021/acs.molpharmaceut.3c00618

データ提供:米国国立医学図書館(NLM)

A Novel Approach to Brain Therapy: Starch-Nimodipine Implants

This study delves into the exciting world of controlled-release drug delivery systems, specifically focusing on the development of a starch-based implant for the sustained release of nimodipine (NMD). NMD is an FDA-approved drug for treating vasospasms caused by subarachnoid hemorrhage (SAH), a life-threatening condition. The study investigates the use of starch as a biocompatible and biodegradable polymer to create a controlled-release system for NMD. This is a promising approach, as it avoids the use of acidic polymers like PLGA, which can lead to drug degradation and inconsistent release profiles. The study demonstrates that starch-based implants can successfully deliver NMD over a period of months, offering a potential solution for the sustained treatment of SAH-induced vasospasms.

Navigating the Desert of Brain Injuries: A New Oasis of Hope

This study highlights the potential of starch-based implants to deliver drugs directly to the brain, offering a targeted and sustained approach to treating neurological conditions. The use of starch as a biocompatible and biodegradable polymer is a significant advancement in drug delivery technology, offering a safe and effective alternative to traditional methods. It's like discovering a new oasis in the heart of the desert, offering a haven of hope for individuals facing neurological challenges.

Sustained Drug Delivery: A New Frontier in Brain Health

The development of controlled-release systems for brain therapies is a rapidly evolving field. This study demonstrates the potential of starch-based implants to deliver drugs over extended periods, improving treatment outcomes and reducing the need for frequent administration. This is like discovering a new wellspring in the desert, providing a steady stream of hydration and nourishment for those in need.

Dr. Camel's Conclusion

This study showcases the exciting potential of starch-based implants for delivering nimodipine (NMD) to the brain. The findings provide evidence for a safe and effective alternative to traditional methods of drug delivery, offering a promising new approach for treating neurological conditions. It's a reminder that innovation in drug delivery can lead to significant breakthroughs in healthcare, transforming the way we treat challenging conditions. This research is a beacon of hope in the desert of brain injuries, illuminating a path towards more effective and personalized therapies.
Date :
  1. Date Completed 2023-11-07
  2. Date Revised 2023-11-08
Further Info :

Pubmed ID

37750866

DOI: Digital Object Identifier

10.1021/acs.molpharmaceut.3c00618

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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